Correlation of Circulating 17β-Oestradiol with Haemostatic Factors in Healthy Postmenopausal Women
| Autor: | M, Mukherjee, F, De Lorenzo, Z, Kadziola, A, Rutlin, N, Ranlall, K, Sembhi, G, Dawson, V V, Kakkar, F, DeLorenzo |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Adult
medicine.medical_specialty 17β-oestradiol Peptide fragment Hormone Replacement Therapy medicine.drug_class medicine.medical_treatment Antithrombin III Biology Statistics Nonparametric Body Mass Index Correlation Endogenous Thrombin Potential Physiology (medical) Internal medicine medicine Humans skin and connective tissue diseases Hemostasis alpha-2-Antiplasmin Postmenopausal women Estradiol Age Factors Hormone replacement therapy (menopause) Hematology Factor VII Middle Aged Blood Coagulation Factors Peptide Fragments Postmenopause Endocrinology Estrogen Female Prothrombin Hormone |
| Zdroj: | Pathophysiology of Haemostasis and Thrombosis. 29:336-342 |
| ISSN: | 1424-8840 1424-8832 |
| DOI: | 10.1159/000022521 |
| Popis: | The aim of the study was to evaluate any correlation between the circulating oestrogenic hormone 17β-oestradiol and haemostatic factors in healthy postmenopausal women. In keeping with this objective, the correlations were evaluated irrespective of whether the source of the hormone was purely endogenous or exogenous as well. Accordingly, a univariate correlation adjusted for age, body mass index, and duration of menopause was determined in 42 healthy postmenopausal women aged 47–78 years, 19 of whom were self-reported users of hormone replacement therapy. The rest were self- reported never users. Serum 17β-oestradiol exhibited a direct correlation with endogenous thrombin potential extrinsic pathway (R = 0.42, p = 0.01) and prothrombin fragments 1 and 2 (R = 0.37, p = 0.03) and an inverse correlation with antithrombin III (R = –0.36, p = 0.03) and α2-antiplasmin (R = –0.45, p = 0.005). The observations suggest an association of this hormone with net thrombin generation on the one hand and improved fibrinolysis on the other. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|