Paracetamol and morphine for infant and neonatal pain; still a long way to go?
| Autor: | Karel Allegaert, Catherijne A. J. Knibbe, Dick Tibboel, Manuel A. Baarslag, Sinno H.P. Simons, John N. van den Anker, Monique van Dijk |
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| Přispěvatelé: | Pediatric Surgery, Pediatrics |
| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
Population Analgesic Neonatal pain Pain Models Biological 03 medical and health sciences 0302 clinical medicine 030225 pediatrics medicine Animals Humans Pharmacology (medical) General Pharmacology Toxicology and Pharmaceutics education Intensive care medicine Acetaminophen education.field_of_study Morphine business.industry Age Factors Infant Newborn Infant General Medicine Analgesics Non-Narcotic Pain management Analgesics Opioid Clinical trial Anesthesia Pharmacodynamics business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Expert Review of Clinical Pharmacology, 10(1), 111-126. Taylor & Francis Ltd |
| ISSN: | 1751-2441 1751-2433 |
| DOI: | 10.1080/17512433.2017.1254040 |
| Popis: | Introduction Pharmacologic pain management in newborns and infants is often based on limited scientific data. To close the knowledge gap, drug-related research in this population is increasingly supported by the authorities, but remains very challenging. This review summarizes the challenges of analgesic studies in newborns and infants on morphine and paracetamol (acetaminophen). Areas covered Aspects such as the definition and multimodal character of pain are reflected to newborn infants. Specific problems addressed include defining pharmacodynamic endpoints, performing clinical trials in this population and assessing developmental changes in both pharmacokinetics and pharmacodynamics. Expert commentary Neonatal and infant pain management research faces two major challenges: lack of clear biomarkers and very heterogeneous pharmacokinetics and pharmacodynamics of analgesics. There is a clear call for integral research addressing the multimodality of pain in this population and further developing population pharmacokinetic models towards physiology-based models. peerreview_statement: The publishing and review policy for this title is described in its Aims & Scope. aims_and_scope_url: http://www.tandfonline.com/action/journalInformation?show=aimsScope&journalCode=ierj20 ispartof: Expert Review of Clinical Pharmacology vol:10 issue:1 pages:111-126 ispartof: location:England status: published |
| Databáze: | OpenAIRE |
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