IFN-γ and IP-10 in tracheal aspirates from premature infants: Relationship with bronchopulmonary dysplasia
| Autor: | Riva Eydelman, Vineet Bhandari, Vishwanath Bhat, Judy G. Saslow, Kartik Mody, Kee H. Pyon, Gary Stahl, Zubair H. Aghai |
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| Rok vydání: | 2012 |
| Předmět: |
Male
Pulmonary and Respiratory Medicine medicine.medical_specialty Pediatrics Birth weight Lung injury Gastroenterology Pathogenesis Interferon-gamma Internal medicine medicine Humans Bronchopulmonary Dysplasia Lung business.industry Infant Newborn Postmenstrual Age Gestational age Tracheal aspirate medicine.disease Body Fluids Chemokine CXCL10 Trachea medicine.anatomical_structure Bronchopulmonary dysplasia Pediatrics Perinatology and Child Health Female business Infant Premature |
| Zdroj: | Pediatric Pulmonology. 48:8-13 |
| ISSN: | 8755-6863 |
| DOI: | 10.1002/ppul.22540 |
| Popis: | Background Interferon-gamma (IFN-γ) and interferon-inducible protein of 10 kDa (IP-10) are potent inflammatory mediators and contribute to acute lung injury in adults. Recently, a potential role for IFN-γ and IP-10 in the pathogenesis of bronchopulmonary dysplasia (BPD) has been reported in animal models. Objective To study the association between IFN-γ and IP-10 in tracheal aspirate (TA) and the development of BPD in premature infants. Design/Methods TA samples collected within 48 hr after birth from 79 mechanically ventilated premature neonates [gestational age (GA) |
| Databáze: | OpenAIRE |
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