Elective percutaneous intervention for intracranial atherosclerotic stenoses by interventional cardiologists
| Autor: | Stephen R. Ramee, Paul W. McMullan, J. Stephen Jenkins, Tyrone J. Collins, Ramy A. Badawi, Christopher J. White, Mark A. Grise, John P. Reilly |
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| Rok vydání: | 2012 |
| Předmět: |
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medicine.medical_specialty Time Factors Percutaneous medicine.medical_treatment Kaplan-Meier Estimate Risk Assessment Disease-Free Survival Recurrence Risk Factors Angioplasty medicine Clinical endpoint Humans Radiology Nuclear Medicine and imaging Hospital Mortality Stroke Aged Retrospective Studies Arterial stenosis business.industry Mortality rate New Orleans Infarction Middle Cerebral Artery General Medicine Middle Aged Intracranial Arteriosclerosis Neurovascular bundle medicine.disease Cerebral Angiography Surgery Catheter Treatment Outcome Ischemic Attack Transient Female Stents Radiology Cardiology and Cardiovascular Medicine business Angioplasty Balloon |
| Zdroj: | Catheterization and Cardiovascular Interventions. 80:121-127 |
| ISSN: | 1522-1946 |
| DOI: | 10.1002/ccd.23439 |
| Popis: | Background: Current “best” medical therapy with anti-platelet and/or anti-thrombotic agents for symptomatic atherosclerotic intracranial (IC) disease is associated with high recurrence. IC catheter-based therapy (CBT) using balloon angioplasty with or without stent placement is an option for patients who have failed medical therapy. We sought to examine the outcomes of CBT for patients with symptomatic IC arterial disease managed by experienced interventional cardiologists. Methods: We retrospectively studied 89 consecutive symptomatic patients with 99 significant (≥70% diameter) IC arterial stenoses who underwent CBT. CBT was performed by experienced interventional cardiologists with the consultative support of a neurovascular team. The primary endpoint was stroke and vascular death. Results: Procedure success was achieved in 96/99 (97%) lesions and percent diameter stenosis was reduced from 91% ± 7.5% preprocedure to 19% ± 15% postprocedure (P < 0.001). The rate of in-hospital periprocedural stroke and all death was 3%. The primary endpoint of stroke and vascular death rate at 1 year was 5.7% (5/88) and at 2 years was 13.5% (11/81). The 2-year all-cause mortality was 11.3% (10/88). Conclusions: For patients with symptomatic IC arterial stenosis who have failed medical therapy or are considered very high risk for stroke, CBT performed by experienced interventional cardiologists is safe and offers both high procedural success rates and excellent clinical outcomes at 1 year. CBT is an attractive option for this high-risk patient population considering the expected 12–15% rate of recurrent stroke at 1 year. © 2012 Wiley Periodicals, Inc. |
| Databáze: | OpenAIRE |
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