RBE variation between fast neutron beams as a function of energy. Intercomparison involving 7 neutrontherapy facilities
| Autor: | P. Chauvel, Adel Courdi, M Octave-Prignot, R. Sabattier, A De Schrijver, Stefaan Vynckier, Lothar Böhm, J Onoda, N. Brassart, Arthur T. Porter, William E. Powers, Mark Yudelev, B M De Coster, Jakobus Slabbert, D. T. L. Jones, Vincent Grégoire, André Wambersie, S El-Akkad, N. Breteau, Richard L. Maughan, John Gueulette, Marc Beauduin, K Strijkmans |
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| Rok vydání: | 1996 |
| Předmět: |
Nuclear reaction
Cell Survival medicine.medical_treatment Mice Inbred Strains Neutron energy spectrum Fast Neutrons Radiotherapy High-Energy Mice Abdomen medicine Relative biological effectiveness Animals Regeneration Radiology Nuclear Medicine and imaging Neutron Irradiation Intestinal Mucosa Fast neutron therapy Physics business.industry Radiochemistry Dose-Response Relationship Radiation Cyclotrons Oncology Gamma Rays Female Protons Nuclear medicine business Dose rate Beam (structure) Relative Biological Effectiveness |
| Zdroj: | Bulletin du cancer. Radiotherapie : journal de la Societe francaise du cancer : organe de la societe francaise de radiotherapie oncologique. |
| ISSN: | 0924-4212 |
| Popis: | In fast neutron therapy, the relative biological effectiveness (RBE) of a given beam varies to a large extent with the neutron energy spectrum. This spectrum depends primarily on the energy of the incident particles and on the nuclear reaction used for neutron production. However, it also depends on other factors which are specific to the local facility, eg, target, collimation system, etc. Therefore direct radiobiological intercomparisons are justified. The present paper reports the results of an intercomparison performed at seven neutrontherapy centres: Orleans, France (p(34)+Be), Riyadh, Saudi Arabia (p(26)+Be), Ghent, Belgium (d(14.5)+Be), Faure, South Africa (p(66)+Be), Detroit, USA (d(48)+Be), Nice, France (p(65)+Be) and Louvain-la-Neuve, Belgium (p(65)+Be). The selected radiobiological system was intestinal crypt regeneration in mice after single fraction irradiation. The observed RBE values (ref cobalt-60 gamma-rays) were 1.79 +/- 0.10, 1.84 +/- 0.07, 2.24 +/- 0.11, 1.55 +/- 0.04, 1.51 +/- 0.03, 1.50 +/- 0.04 and 1.52 +/- 0.04, respectively. When machine availability permitted, additional factors were studied: two vs one fraction (Ghent, Louvain-la-Neuve), dose rate (Detroit), influence of depth in phantom (Faure, Detroit, Nice, Louvain-la-Neuve). In addition, at Orleans and Ghent, RBEs were also determined for LD50 at 6 days after selective abdominal irradiation and were found to be equal to the RBEs for crypt regeneration. The radiobiological intercomparisons were always combined with direct dosimetric intercomparisons and, when possible in some centres, with microdosimetric investigations. |
| Databáze: | OpenAIRE |
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