Poly(A)-binding proteins and mRNA localization: who rules the roost?
| Autor: | Richard P. Smith, Lenka Hrabalkova, Jessica P. Scanlon, Nicola K. Gray |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Cell Nucleus
Messenger RNA Cytoplasm biology RNA Stability Active Transport Cell Nucleus Translation (biology) Biochemistry Molecular biology Poly(A)-Binding Proteins Cell biology Cell nucleus Stress granule medicine.anatomical_structure Protein Biosynthesis Poly(A)-binding protein biology.protein medicine Protein biosynthesis Animals Humans RNA Messenger Poly A Nucleus |
| Zdroj: | Biochemical Society transactions. 43(6) |
| ISSN: | 1470-8752 |
| Popis: | RNA-binding proteins are often multifunctional, interact with a variety of protein partners and display complex localizations within cells. Mammalian cytoplasmic poly(A)-binding proteins (PABPs) are multifunctional RNA-binding proteins that regulate multiple aspects of mRNA translation and stability. Although predominantly diffusely cytoplasmic at steady state, they shuttle through the nucleus and can be localized to a variety of cytoplasmic foci, including those associated with mRNA storage and localized translation. Intriguingly, PABP sub-cellular distribution can alter dramatically in response to cellular stress or viral infection, becoming predominantly nuclear and/or being enriched in induced cytoplasmic foci. However, relatively little is known about the mechanisms that govern this distribution/relocalization and in many cases PABP functions within specific sites remain unclear. Here we discuss the emerging evidence with respect to these questions in mammals. |
| Databáze: | OpenAIRE |
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