Early radiotherapy preserves vision in sporadic optic pathway glioma
| Autor: | Alexander N. Hanania, Patricia Baxter, Arnold C. Paulino, Veeral Shah, Murali Chintagumpala, Susan L. McGovern, Mary Frances McAleer, Jack Su, David R. Grosshans, M. Fatih Okcu, Ethan B. Ludmir |
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| Rok vydání: | 2021 |
| Předmět: |
Optic Nerve Glioma
Cancer Research medicine.medical_specialty Visual acuity medicine.medical_treatment Vision Disorders Visual Acuity Salvage therapy 03 medical and health sciences 0302 clinical medicine Interquartile range Glioma medicine Humans 030212 general & internal medicine Child Retrospective Studies Salvage Therapy Chemotherapy business.industry Infant Cancer medicine.disease Radiation therapy Oncology Child Preschool 030220 oncology & carcinogenesis Cohort Radiology medicine.symptom business Follow-Up Studies |
| Zdroj: | Cancer. 127:2358-2367 |
| ISSN: | 1097-0142 0008-543X |
| DOI: | 10.1002/cncr.33497 |
| Popis: | BACKGROUND Sporadic optic pathway/hypothalamic gliomas represent a unique entity within pediatric low-grade glioma. Despite favorable survival, location makes treatment difficult and local progression debilitating. This study is a longitudinal assessment of visual acuity (VA) among children treated within the last 2 decades. METHODS Clinical characteristics were abstracted for patients treated from 2000 to 2018 at Texas Children's Cancer Center in Houston. Ophthalmologic data taken at 3- to 6-month intervals were examined with age-appropriate VA metrics converted to the LogMAR (logarithm of the minimum angle of resolution) scale. Kaplan-Meier blindness-free survival (BFS) curves, calculated as time-to-bilateral functional blindness (LogMAR ≥0.8 in both eyes), were calculated for patients receiving early radiation therapy (RT; upfront or as first-line salvage treatment) or chemotherapy (CT) and evaluated using the log-rank test. RESULTS Thirty-eight patients with a median follow-up of 8.5 years (range, 2-17 years) were identified. Median age at diagnosis was 3 years (interquartile range |
| Databáze: | OpenAIRE |
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