Pseudomonas aeruginosa: An Audacious Pathogen with an Adaptable Arsenal of Virulence Factors
| Autor: | Maite Sainz-Mejías, Siobhán McClean, Irene Jurado-Martín |
|---|---|
| Jazyk: | angličtina |
| Předmět: |
0301 basic medicine
Pseudomonas aeruginosa virulence factors adaptation cystic fibrosis diversity genomics lung environment 030106 microbiology Virulence Genomics Review Biology medicine.disease_cause Catalysis Microbiology Inorganic Chemistry lcsh:Chemistry 03 medical and health sciences medicine Physical and Theoretical Chemistry Molecular Biology Pathogen lcsh:QH301-705.5 Spectroscopy Organic Chemistry General Medicine 3. Good health Computer Science Applications 030104 developmental biology lcsh:Biology (General) lcsh:QD1-999 Adaptation |
| Zdroj: | International Journal of Molecular Sciences International Journal of Molecular Sciences, Vol 22, Iss 3128, p 3128 (2021) PubMed Central Sygma ORCID DOAJ-Articles |
| ISSN: | 1422-0067 |
| DOI: | 10.3390/ijms22063128 |
| Popis: | Pseudomonas aeruginosais a dominant pathogen in people with cystic fibrosis (CF) contributing to morbidity and mortality. Its tremendous ability to adapt greatly facilitates its capacity to cause chronic infections. The adaptability and flexibility of the pathogen are afforded by the extensive number of virulence factors it has at its disposal, providingP. aeruginosawith the facility to tailor its response against the different stressors in the environment. A deep understanding of these virulence mechanisms is crucial for the design of therapeutic strategies and vaccines against this multi-resistant pathogen. Therefore, this review describes the main virulence factors ofP. aeruginosaand the adaptations it undergoes to persist in hostile environments such as the CF respiratory tract. The very largeP. aeruginosagenome (5 to 7 MB) contributes considerably to its adaptive capacity; consequently, genomic studies have provided significant insights into elucidatingP. aeruginosaevolution and its interactions with the host throughout the course of infection. |
| Databáze: | OpenAIRE |
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