Understanding Nanomaterial Biotransformation: An Unmet Challenge to Achieving Predictive Nanotoxicology
| Autor: | Peter Wick, Ana Milosevic, Daina Romeo |
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| Rok vydání: | 2020 |
| Předmět: |
Process (engineering)
Computer science 02 engineering and technology General Chemistry Toxicology 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences Nanostructures 0104 chemical sciences Biomaterials Oxidative Stress Risk analysis (engineering) Multidisciplinary approach Nanotoxicology Computer Simulation General Materials Science 0210 nano-technology Biotransformation Biotechnology |
| Zdroj: | Small. 16:1907650 |
| ISSN: | 1613-6829 1613-6810 |
| DOI: | 10.1002/smll.201907650 |
| Popis: | More than a decade has passed since the first concepts of predictive nanotoxicology were formulated. During this time, many advancements have been achieved in multiple disciplines, including the success stories of the fiber paradigm and the oxidative stress paradigm. However, important knowledge gaps are slowing down the development of predictive nanotoxicology and require a mutidisciplinary effort to be overcome. Among these gaps, understanding, reproducing, and modeling of nanomaterial biotransformation in biological environments is a central challenge, both in vitro and in silico. This dynamic and complex process is still a challenge for today's bioanalytics. This work explores and discusses selected approaches of the multidisciplinary efforts taken in the last decade and the challenges that remain unmet, in particular concerning nanomaterial biotransformation. It highlights some future advancements that, together, can help to understand such complex processes and accelerate the development of predictive nanotoxicology. |
| Databáze: | OpenAIRE |
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