Development of ciprofloxacin-loaded contact lenses using fluorous chemistry
| Autor: | Guoting Qin, Siheng Li, Alison M. McDermott, Chengzhi Cai, Zhiling Zhu |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Contact Lenses
Swine Nanofibers Biophysics Administration Ophthalmic Bioengineering 02 engineering and technology In Vitro Techniques Eye Infections Bacterial Article Biomaterials 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Ciprofloxacin medicine Animals Humans Fluorescein Cytotoxicity Drug Implants Chromatography Chemistry Biological activity Equipment Design Eye infection 021001 nanoscience & nanotechnology Antimicrobial eye diseases Anti-Bacterial Agents Equipment Failure Analysis Treatment Outcome Mechanics of Materials Drug delivery 030221 ophthalmology & optometry Ceramics and Composites sense organs Fluorous chemistry 0210 nano-technology medicine.drug Biomedical engineering |
| Zdroj: | Biomaterials. 124:55-64 |
| ISSN: | 0142-9612 |
| DOI: | 10.1016/j.biomaterials.2017.01.046 |
| Popis: | In this work, we developed a simple method to load drugs into commercially available contact lenses utilizing fluorous chemistry. We demonstrated this method using model compounds including fluorous-tagged fluorescein and antibiotic ciprofloxacin. We showed that fluorous interactions facilitated the loading of model molecules into fluorocarbon-containing contact lenses, and that the release profiles exhibited sustained release. Contact lenses loaded with fluorous-tagged ciprofloxacin exhibited antimicrobial activity against Pseudomonas aeruginosa in vitro, while no cytotoxicity towards human corneal epithelial cells was observed. To mimic the tear turnover, we designed a porcine eye infection model under flow conditions. Significantly, the modified lenses also exhibited antimicrobial efficacy against Pseudomonas aeruginosa in the ex vivo infection model. Overall, utilizing fluorous chemistry, we can construct a drug delivery system that exhibits high drug loading capacity, sustained drug release, and robust biological activity. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect