Murine diffusion imaging using snapshot interleaved EPI acquisition at 7 Tesla
| Autor: | David N. Guilfoyle, Jan Hrabe, Scott Gerum |
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| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Male
Article Corpus Callosum White matter Mice Nuclear magnetic resonance Fractional anisotropy medicine Quantitative assessment Image Processing Computer-Assisted Animals Physics Echo-planar imaging Cerebral Cortex medicine.diagnostic_test Echo-Planar Imaging General Neuroscience Brain Magnetic resonance imaging Signal Processing Computer-Assisted Organ Size Mice Inbred C57BL Diffusion imaging medicine.anatomical_structure Diffusion Magnetic Resonance Imaging Snapshot (computer storage) Anisotropy Diffusion MRI |
| Popis: | Diffusion Tensor Imaging (DTI) is a powerful magnetic resonance imaging tool for quantitative assessment of white matter micro structure. The majority of DTI methods employ Echo Planar Imaging (EPI) because it is insensitive to motion. However, EPI suffers from distortions and signal losses induced by inhomogeneities in magnetic field susceptibility. This is particularly accentuated in murine imaging at very high magnetic fields. The purpose of this study is to demonstrate that a Snapshot Interleaved EPI acquisition block combined with a stimulated echo module for diffusion sensitization can be successfully used to obtain high quality DTI of a mouse brain at 7 Tesla. This technique preserves the EPI speed but reduces its susceptibility artifacts and signal losses. Signal to noise ratio is also reduced but remains higher than in the DTI acquisitions based on a fast low angle shot technique. In vivo results using this new approach are presented along with a full description of the methodology. |
| Databáze: | OpenAIRE |
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