Inverse Modeling Framework for Characterizing Patient-specific Microstructural Changes in the Pulmonary Arteries
| Autor: | C. Alberto Figueroa, Christopher Tossas-Betancourt, Zhenxiang Jiang, Lik Chuan Lee, Reza Pourmodheji, Seungik Baek |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Myocytes
Smooth Muscle Biomedical Engineering 02 engineering and technology Pulmonary arterial pressure Pulmonary Artery Article Biomaterials 03 medical and health sciences 0302 clinical medicine Smooth muscle medicine.artery medicine Humans Child Lung biology medicine.diagnostic_test Chemistry Stiffness Magnetic resonance imaging 030206 dentistry Patient specific 021001 nanoscience & nanotechnology Elastin Mechanics of Materials Pulmonary artery biology.protein Transplant patient medicine.symptom 0210 nano-technology Biomedical engineering |
| Zdroj: | J Mech Behav Biomed Mater |
| Popis: | Microstructural changes in the pulmonary arteries associated with pulmonary arterial hypertension (PAH) is not well understood and characterized in humans. To address this issue, we developed and applied a patient-specific inverse finite element (FE) modeling framework to characterize mechanical and structural changes of the micro-constituents in the proximal pulmonary arteries using in-vivo pressure measurements and magnetic resonance images. The framework was applied using data acquired from a pediatric PAH patient and a heart transplant patient with normal pulmonary arterial pressure, which serves as control. Parameters of a constrained mixture model that are associated with the structure and mechanical properties of elastin, collagen fibers and smooth muscle cells were optimized to fit the patient-specific pressure-diameter responses of the main pulmonary artery. Based on the optimized parameters, individual stress and linearized stiffness resultants of the three tissue constituents, as well as their aggregated values, were estimated in the pulmonary artery. Aggregated stress resultant and stiffness are, respectively, 4.6 and 3.4 times higher in the PAH patient than the control subject. Stress and stiffness resultants of each tissue constituent are also higher in the PAH patient. Specifically, the mean stress resultant is highest in elastin (PAH: 69.96, control: 14.42 kPa-mm), followed by those in smooth muscle cell (PAH: 13.95, control: 4.016 kPa-mm) and collagen fibers (PAH: 13.19, control: 2.908 kPa-mm) in both the PAH patient and the control subject. This result implies that elastin may be the key load-bearing constituent in the pulmonary arteries of the PAH patient and the control subject. |
| Databáze: | OpenAIRE |
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