Comparable profiles of serum histamine and IgG4 levels in allergic beekeepers
| Autor: | M. Makris, Dimitrios Rigopoulos, Xenophon Aggelides, Alexandros Katoulis, Caterina Chliva, Ekaterini Tiligada |
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| Rok vydání: | 2015 |
| Předmět: |
Male
Allergy Immunology Pilot Projects Biology medicine.disease_cause Positive correlation Honeybee venom chemistry.chemical_compound Allergen Immunoglobulin g4 Hypersensitivity Immune Tolerance medicine Humans Immunology and Allergy Insect Bites and Stings Total ige Allergens Immunoglobulin E medicine.disease Bee Venoms Sting chemistry Immunoglobulin G Female Histamine |
| Zdroj: | Allergy. 70:457-460 |
| ISSN: | 0105-4538 |
| DOI: | 10.1111/all.12568 |
| Popis: | Growing evidence identifies histamine as a key player in allergic responses, but the reports relating serum histamine to tolerance are scarce and inconclusive. This study investigated the relationship of circulating histamine to the tolerant phenotype in allergic beekeepers. The results showed a positive correlation between the serum levels of histamine and specific immunoglobulin G4 (sIgG4) to honeybee venom, but not with total IgE or sIgE. Interestingly, both sIgG4 and histamine levels were negatively correlated with the time since the last bee sting. In contrast to total IgE and sIgE, serum sIgG4 and histamine levels followed comparable patterns, being higher in tolerant/recently stung individuals and lower in the least frequently stung subgroup. The data obtained in this pilot study associated, for the first time, serum histamine levels with allergen tolerance in allergic individuals and provided the lead for further considering the putative immunomodulatory properties of histamine in allergic responses. |
| Databáze: | OpenAIRE |
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