Phytochemical and Immunomodulatory Properties of an Echinacea laevigata (Asteraceae) Tincture
| Autor: | Chinh T. Dao, Amila S. Dias, Nisarg B. Shah, Brad K. Laflen, Jennifer H. Strauch, Breanna L. Dumke, David S. Senchina, Griffin B. Hoffmann, M. Ann D. N. Perera |
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| Rok vydání: | 2011 |
| Předmět: |
Mononuclear cell proliferation
Echinacea laevigata Plant Roots Peripheral blood mononuclear cell Echinacea chemistry.chemical_compound Species Specificity Humans Immunologic Factors Medicine Glycosides Cells Cultured Chromatography High Pressure Liquid Cell Proliferation Traditional medicine biology Plant Extracts business.industry Interleukin Tincture biology.organism_classification Complementary and alternative medicine Phytochemical chemistry Leukocytes Mononuclear Echinacoside Cytokines business |
| Zdroj: | The Journal of Alternative and Complementary Medicine. 17:375-377 |
| ISSN: | 1557-7708 1075-5535 |
| Popis: | Echinacea preparations are consumed for the prevention or treatment of upper respiratory infections.The objective of this study was to provide the first data regarding the in vitro immunomodulatory properties of the American federally endangered species Echinacea laevigata (Asteraceae).Human peripheral blood mononuclear cells were cultured with root tinctures from E. laevigata, E. angustifolia, E. pallida, and E. purpurea. Cytokine production (tumor necrosis factor [TNF], interleukin [IL]-2, IL-10) and mononuclear cell proliferation were measured. High-performance liquid chromatography was used to assay levels of known bioactive compounds from all extracts tested to statistically determine whether there were relationships between extract phytochemical content and observed immune effects.E. laevigata extract was most similar to E. pallida extract and able to augment IL-10 and mononuclear cell proliferation, but not TNF or IL-2. Echinacoside, a caffeic acid derivative, correlated most strongly with results.This species may deserve continued investigation in both experimental and therapeutic contexts. |
| Databáze: | OpenAIRE |
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