Full-length Transcriptome-based H-InvDB Throws a New Light on Chromosome-centric Proteomics
| Autor: | Sayaka Mikami, Chisato Yamasaki, Takuya Habara, Yasuhiko Bando, Yoko Nagai, Toshihide Nishimura, Jun-ichi Takeda, Hiromasa Tojo, Tadashi Imanishi |
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| Rok vydání: | 2012 |
| Předmět: |
DNA
Complementary Databases Factual Proteome Genome Human Gene Expression Profiling Gene Expression Proteins Chromosome General Chemistry Computational biology Biology Proteomics Biochemistry Genome Mass Spectrometry Gene expression profiling Transcriptome Human Genome Project Humans Integrated database Human genome |
| Zdroj: | Journal of Proteome Research. 12:62-66 |
| ISSN: | 1535-3907 1535-3893 |
| DOI: | 10.1021/pr300861a |
| Popis: | H-Invitational Database (H-InvDB; http://hinv.jp/ ) is an integrated database of all human genes and transcripts that started in an international collaborative research project for establishing a functional annotation database of human full-length cDNAs. Because H-InvDB contains an abundance of information for human transcripts, including not only well-characterized protein-coding transcripts but also those without experimental evidence at the protein level, this will be a useful information resource for identifying novel and uncharacterized human proteins (so-called missing proteins). By extending predicted protein data in H-InvDB, we developed the H-Inv Extended Protein Database (H-EPD; http://hinv.jp/hinv/h-epd/ ). From now on, we plan to carry out a database-driven proteome research that makes full use of H-EPD to promote discoveries in the current and future C-HPP. Furthermore, we will push forward with the integration of genome, transcriptome, and proteome databases using a unique tool for connecting distributed databases and would like to develop a knowledge discovery system by incorporating data mining tools. |
| Databáze: | OpenAIRE |
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