Morphology of colorectal lymphoid aggregates in cancer, diverticular and inflammatory bowel diseases
| Autor: | Vincenzo Villanacci, Ernesto Di Betta, Francesco Di Fabio, Simona Fisogni, Mariani Pp, Riccardo Nascimbeni |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Adult
Male medicine.medical_specialty Pathology CD3 Complex crohn's disease Colorectal cancer H&E stain colorectal cancer Diverticulum Colon Gastroenterology Pathology and Forensic Medicine Pathogenesis Peyer's Patches Crohn Disease Internal medicine medicine Humans Colitis ulcerative colitis Acetic Acid Aged Aged 80 and over Crohn's disease Histocytochemistry business.industry lymphoid aggregates Cancer Middle Aged Antigens CD20 Inflammatory Bowel Diseases medicine.disease Immunohistochemistry Ulcerative colitis digestive system diseases Ki-67 Antigen Diverticular disease Colitis Ulcerative Female Colorectal Neoplasms business |
| Zdroj: | Modern Pathology. 18:681-685 |
| ISSN: | 0893-3952 |
| DOI: | 10.1038/modpathol.3800343 |
| Popis: | The present study compares the characteristics of colorectal lymphoid aggregates in patients with carcinoma, diverticular disease, Crohn's disease, or ulcerative colitis of the large bowel. A total of 77 patients (41 colorectal cancer, 27 diverticular disease, six ulcerative colitis, three Crohn's disease) undergoing colorectal resection were included. Acetic acid staining, hematoxylin and eosin staining, CD3, CD20, and MIB1 immunostaining were employed in order to assess density, diameter, subepithelial or basal location, cellular profile, and proliferation of lymphoid aggregates in normal-appearing and actively inflamed large bowel. In normal-appearing tissue, mean density of lymphoid aggregates was lower in patients with ulcerative colitis and Crohn's disease than in those with colorectal cancer or diverticular disease. A larger mean diameter of aggregates was observed in patients with Crohn's disease. In inflammatory bowel diseases, a marked increase of the mean density of lymphoid aggregates was observed in actively affected specimens. In Crohn's disease more than in ulcerative colitis, the aggregates had a predominant basal or transmural distribution. In diverticular disease, active inflammation determined a less significant increase of subepithelial aggregates harboring a lower proportion of germinal centers. No significant variations of CD3, CD20, and MIB1 were recorded among the four disease groups. The lymphoid aggregate derangements observed not only in the actively affected mucosa but also in the unaffected colorectal lining of patients with Crohn's disease and ulcerative colitis support a relevant involvement of lymphoid aggregate system in the pathogenesis of inflammatory bowel diseases. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|