Julichrome Q6 Glucuronide, a Monomeric Subunit of the Julimycin B-I Complex from a Terrestrial Streptomyces sp
| Autor: | Armin Maier, Heinz H. Fiebig, Iris Grün-Wollny, Mohamed Shaaban, Hartmut Laatsch, Khaled A. Shaaban |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Stereochemistry
Protein subunit Pharmaceutical Science Glucuronates Marine Biology Chlorella Factor VIIa Microbial Sensitivity Tests Naphthalenes 010402 general chemistry 01 natural sciences Streptomyces Analytical Chemistry chemistry.chemical_compound 2-Naphthylamine Candida albicans Drug Discovery Nuclear Magnetic Resonance Biomolecular Pharmacology Bacteria Molecular Structure biology 010405 organic chemistry Organic Chemistry biology.organism_classification Recombinant Proteins 0104 chemical sciences 1-Naphthylamine Monomer Complementary and alternative medicine chemistry Molecular Medicine Drug Screening Assays Antitumor Glucuronide Two-dimensional nuclear magnetic resonance spectroscopy Nosiheptide |
| Zdroj: | Journal of Natural Products. 70:1545-1550 |
| ISSN: | 1520-6025 0163-3864 |
| Popis: | The terrestrial Streptomyces sp. isolate GW6225 afforded julichrome Q 6 glucuronide ( 9), the first monomeric member of the julimycin-B complex, and additionally the julichromes Q 1.2 ( 7a), Q 1.5 ( 7b), and Q 3.5 ( 8), which were fully characterized by 2D NMR spectra. Additional new microbial compounds were 4-acetylchrysophanol ( 6a) and N-phenyl-beta-naphthylamine ( 10). The isomeric N-phenyl-alpha-naphthylamine ( 11) was found in the marine Streptomyces sp. B8335 and was also characterized. The high antibiotic activity of Streptomyces sp. GW6225 extracts was probably due to the thiazolyl cyclopeptide nosiheptide. |
| Databáze: | OpenAIRE |
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