Transient severe hypotension with once-weekly subcutaneous injection of teriparatide in osteoporotic patient: a case report and insight for the drug interaction between hypotensive agents and teriparatide
| Autor: | Nori Sato, Shinsuke Katoh, Hirokazu Uemura, Masanori Inatsugi, Kei Inatsugi, Tetsuya Enishi, Sho Minato, Koichi Siryo, Mikiko Inatsugi |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
side effect Side effect Nausea Injections Subcutaneous Osteoporosis Blood Pressure Asymptomatic General Biochemistry Genetics and Molecular Biology Subcutaneous injection Teriparatide Heart rate medicine Humans Drug Interactions Antihypertensive Agents Osteoporosis Postmenopausal Aged 80 and over Bone Density Conservation Agents business.industry General Medicine medicine.disease osteoporosis Surgery Blood pressure Hypertension Female medicine.symptom Hypotension business medicine.drug |
| Zdroj: | The journal of medical investigation : JMI. 62(1-2) |
| ISSN: | 1349-6867 |
| Popis: | Teriparatide, a recombinant form of parathyroid hormone, were well recognized as a useful option for the treatment of the osteoporosis. Although some side effects of teriparatide include headache, nausea, dizziness, and limb pain were reported. Here we present a 80-year-old woman of transient asymptomatic hypotension with once-weekly subcutaneous injection of teriparatide for the treatment of osteoporosis with hypertension disease as acute-phase reactions. Systolic blood pressure decreased in both 30 min and 60 min after injection compared with before injection. Heart rate increased with passage of time. Statistically significant were observed among before, 30 min, 60 min after injection of teriparatide. Slight nausea was seen as subjective symptoms with the first and second injection after 30 min. This case indicates careful attention, at least 1 hr, was recommended with weekly subcutaneous injections of teriparatide in the treatment for osoteoproteic patient with hypertension decreases. This is a first report, to the best of our knowledge, to demonstrate the transient asymptomatic hypotension after once-weekly injection of teriparatide with hypertension disease. Transient hypotension occurred after injection of teriparatide during the treatment period and was asymptomatic except for the first 2 injections. |
| Databáze: | OpenAIRE |
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