Quantitative assessment of left ventricular longitudinal function and myocardial deformation in Duchenne muscular dystrophy patients

Autor:	Martin Pešl, Lenka Juříková, Vladimír Kincl, Mary Luz Mojica-Pisciotti, Tomáš Holeček, Lukáš Opatřil, Lucia Masárová, Eva Pešlová, Věra Feitová, Jan Máchal, Roman Panovský
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	Male Duchenne muscular dystrophy medicine.medical_specialty Longitudinal strain Cardiac magnetic resonance lcsh:Medicine 030204 cardiovascular system & hematology Strain analysis Ventricular Function Left 030218 nuclear medicine & medical imaging 03 medical and health sciences Ventricular Dysfunction Left 0302 clinical medicine Internal medicine medicine Quantitative assessment Circumferential strain Humans Pharmacology (medical) Longitudinal function cardiovascular diseases Genetics (clinical) business.industry Myocardium Research lcsh:R Skeletal muscle General Medicine medicine.disease Muscular Dystrophy Duchenne Feature tracking medicine.anatomical_structure Cardiology business Cardiomyopathies
Zdroj:	Orphanet Journal of Rare Diseases, Vol 16, Iss 1, Pp 1-9 (2021) Orphanet Journal of Rare Diseases
ISSN:	1750-1172
Popis:	Background Duchenne muscular dystrophy (DMD) manifests in males mainly by skeletal muscle impairment, but also by cardiac dysfunction. The assessment of the early phases of cardiac involvement using echocardiography is often very difficult to perform in these patients. The aim of the study was to use cardiac magnetic resonance (CMR) strain analysis and mitral annular plane systolic excursion (MAPSE) in the detection of early left ventricular (LV) dysfunction in DMD patients. Methods and results In total, 51 male DMD patients and 18 matched controls were examined by CMR. MAPSE measurement and functional analysis using feature tracking (FT) were performed. Three groups of patients were evaluated: A/ patients with LGE and LV EF Groups A and B had significantly reduced values of MAPSE, global longitudinal strain (GLS), global circumferential strain (GCS), and global radial strain (GRS) in comparison to controls (p p Conclusion DMD patients had decreased LV systolic function measured by MAPSE and global LV strain even in the case of normal LV EF and the absence of LGE. FT and MAPSE measurement provide sensitive assessment of early cardiac involvement in DMD patients.
Databáze:	OpenAIRE
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