Cardiac and placental mitochondrial characterization in a rabbit model of intrauterine growth restriction

Autor: Eduard Gratacós, Ingrid González-Casacuberta, O. Ugarteburu, Fatima Crispi, M. Catalán-Garcia, Francesc Cardellach, Ester Tobías, Josep Maria Grau, J.C. Milisenda, Constanza Morén, Diana Luz Juárez-Flores, Anna Gonzalez-Tendero, A. Cortés, S. Niñerola, F. Tort, María V. Cascajo, Glòria Garrabou, Mariona Guitart-Mampel, L. Matalonga
Přispěvatelé: Instituto de Salud Carlos III, Generalitat de Catalunya, Consejo Nacional de Ciencia y Tecnología (México), Fundació La Marató de TV3, Fundació Privada Cellex, Fundación 'la Caixa', Universitat de Barcelona, Obra Social la Caixa
Rok vydání: 2018
Předmět:
0301 basic medicine
Bioenergetics
Cardiovascular function
Fetal growth
Mitochondrial complex II
Mitochondrial dysfunction
Rabbit animal model
Sirtuin3
Placenta
Intrauterine growth restriction
Fetal growth
Obstetric complication
Biochemistry
Rabbit animal model
Mitochondria
Heart
Mitocondris
Transcriptome
Pregnancy
Sirtuin 3
Conills
reproductive and urinary physiology
chemistry.chemical_classification
Fetal Growth Retardation
Heart
Mitochondria
Obstetrics
embryonic structures
Female
Rabbits
medicine.medical_specialty
Biophysics
Mitochondrial Proteins
03 medical and health sciences
Internal medicine
medicine
Animals
Sirtuin3
Cor
Molecular Biology
Creixement fetal
business.industry
Embryogenesis
medicine.disease
Cardiovascular function
Mitochondrial complex II
Disease Models
Animal
030104 developmental biology
Enzyme
Endocrinology
chemistry
Rabbit model
business
Obstetrícia
Mitochondrial dysfunction
Function (biology)
Zdroj: BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
r-FSJD: Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
Fundació Sant Joan de Déu
Digital.CSIC. Repositorio Institucional del CSIC
instname
r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
Recercat. Dipósit de la Recerca de Catalunya
Dipòsit Digital de la UB
Universidad de Barcelona
Digital.CSIC: Repositorio Institucional del CSIC
Consejo Superior de Investigaciones Científicas (CSIC)
ISSN: 1388-1981
Popis: [Background]: Intrauterine growth restriction (IUGR) is associated with cardiovascular remodeling persisting into adulthood. Mitochondrial bioenergetics, essential for embryonic development and cardiovascular function, are regulated by nuclear effectors as sirtuins. A rabbit model of IUGR and cardiovascular remodeling was generated, in which heart mitochondrial alterations were observed by microscopic and transcriptomic analysis. We aimed to evaluate if such alterations are translated at a functional mitochondrial level to establish the etiopathology and potential therapeutic targets for this obstetric complication. [Methods]: Hearts and placentas from 16 IUGR-offspring and 14 controls were included to characterize mitochondrial function. [Results]: Enzymatic activities of complexes II, IV and II + III in IUGR-hearts (−11.96 ± 3.16%; −15.58 ± 5.32%; −14.73 ± 4.37%; p
This work was supported by Fondo de Investigación Sanitaria [FIS PI12/01199, PI15/00817, PI15/00903 and PI15/00130], CIBERER (an initiative of ISCIII) and InterCIBER [PIE1400061] granted by Instituto de Salud Carlos III and cofinanced by the Fondo Europeo de Desarrollo Regional de la Unión Europea “Una manera de hacer Europa”; Suports a Grups de Recerca [SGR893/2017] and CERCA Programme from the Generalitat de Catalunya; CONACyT; Fundació La Marató de TV3 [87/C/2015]; Fundació Cellex; and “la Caixa” Foundation.
Databáze: OpenAIRE
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