Lifelong Physical Activity Determines Vascular Function in Late Postmenopausal Women
| Autor: | Jon Egelund, Ylva Hellsten, Andrea Tamariz-Ellemann, Nicolai Rytter, Howard H. Carter, Nina Brandt, Lasse Gliemann |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Nitroprusside
Muscle tissue medicine.medical_specialty Endothelium Vasodilator Agents Physical Therapy Sports Therapy and Rehabilitation Prostacyclin Vasodilation 6-Ketoprostaglandin F1 alpha Femoral artery Muscle Smooth Vascular Nitric oxide Norepinephrine chemistry.chemical_compound Internal medicine medicine.artery medicine Humans Orthopedics and Sports Medicine Muscle Skeletal Exercise Aged Leg business.industry Middle Aged Epoprostenol Acetylcholine Femoral Artery Postmenopause Cross-Sectional Studies medicine.anatomical_structure Endocrinology chemistry Regional Blood Flow Female Endothelium Vascular Sodium nitroprusside business medicine.drug |
| Zdroj: | Medicine & Science in Sports & Exercise. 52:627-636 |
| ISSN: | 1530-0315 0195-9131 |
| DOI: | 10.1249/mss.0000000000002180 |
| Popis: | Introduction The study evaluated the role of lifelong physical activity for leg vascular function in postmenopausal women (61 ± 1 yr). Method The study design was cross-sectional with three different groups based on self-reported physical activity level with regard to intensity and volume over the past decade: inactive (n = 14), moderately active (n = 12), and very active (n = 15). Endothelial-dependent and smooth muscle-dependent leg vascular function were assessed by ultrasound Doppler measurements of the femoral artery during infusion of acetylcholine (Ach), the nitric oxide (NO) donor sodium nitroprusside and the prostacyclin analog epoprostenol. Thigh muscle biopsies, arterial and venous plasma samples were obtained for assessment of vasodilator systems. Results The very active group was found to have 76% greater responsiveness to Ach compared with the sedentary group accompanied by 200% higher prostacyclin synthesis during Ach infusion. Smooth muscle cell responsiveness to sodium nitroprusside and epoprostenol was not different between groups. The protein amount of endothelial NO synthase and endogenous antioxidant enzymes in muscle tissue was higher in the very active than the inactive group. The moderately active group had a similar endothelial and smooth muscle cell responsiveness as the inactive group. A secondary comparison with a smaller group (n = 5) of habitually active young (24 ± 2 yr) women indicated that smooth muscle cell responsiveness and endothelial responsiveness are affected by age per se. Conclusions This study shows that leg vascular function and the potential to form prostacyclin and NO in late postmenopausal women, is influenced by the extent of lifelong physical activity. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|