Genome-wide chromatin and gene expression profiling during memory formation and maintenance in adult mice
| Autor: | Rashi Halder, Ramon O. Vidal, Orr Shomroni, Tonatiuh Pena Centeno, Stefan Bonn, Magali Hennion, Raza-Ur Rahman |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Data descriptor Statistics and Probability Data Descriptor Memory Long-Term Gene regulatory network Fear conditioning Computational biology chromatin gene expression adult mice Biology Library and Information Sciences Biochemistry biophysics & molecular biology [F05] [Life sciences] Gene regulatory networks Epigenesis Genetic Education Histones Mice 03 medical and health sciences Epigenetics and behaviour Sequencing Animals Epigenetics Biochimie biophysique & biologie moléculaire [F05] [Sciences du vivant] Genetics Gene Expression Profiling DNA Methylation genetics [Histones] Chromatin Computer Science Applications Metadata Gene expression profiling genetics [Chromatin] 030104 developmental biology Histone DNA methylation biology.protein ddc:500 Statistics Probability and Uncertainty Genome-Wide Association Study Information Systems |
| Zdroj: | Scientific Data. London, United Kingdom: Nature Publishing Group (2016). Scientific Data Scientific data 3(1), 160090 (2016). doi:10.1038/sdata.2016.90 |
| DOI: | 10.1038/sdata.2016.90 |
| Popis: | Recent evidence suggests that the formation and maintenance of memory requires epigenetic changes. In an effort to understand the spatio-temporal extent of learning and memory-related epigenetic changes we have charted genome-wide histone and DNA methylation profiles, in two different brain regions, two cell types, and three time-points, before and after learning. In this data descriptor we provide detailed information on data generation, give insights into the rationale of experiments, highlight necessary steps to assess data quality, offer guidelines for future use of the data and supply ready-to-use code to replicate the analysis results. The data provides a blueprint of the gene regulatory network underlying short- and long-term memory formation and maintenance. This ‘healthy’ gene regulatory network of learning can now be compared to changes in neurological or psychiatric diseases, providing mechanistic insights into brain disorders and highlighting potential therapeutic avenues. Machine-accessible metadata file describing the reported data (ISA-Tab format) |
| Databáze: | OpenAIRE |
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