Low level of tissue plasminogen activator activity in non-diabetic patients with a first myocardial infarction
| Autor: | B Dinesen, Michael E Røder, Mats Eliasson, Dan Lundblad, Aslak Rautio |
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| Rok vydání: | 2005 |
| Předmět: |
Male
medicine.medical_specialty Heart disease medicine.medical_treatment Hypercholesterolemia Myocardial Infarction Tissue plasminogen activator Body Mass Index Cohort Studies chemistry.chemical_compound Risk Factors Internal medicine Diabetes mellitus Plasminogen Activator Inhibitor 1 Fibrinolysis Internal Medicine medicine Humans Insulin Myocardial infarction Triglycerides Analysis of Variance business.industry T-plasminogen activator Fibrinogen Glucose Tolerance Test Middle Aged medicine.disease Lipids Endocrinology chemistry Case-Control Studies Tissue Plasminogen Activator Plasminogen activator inhibitor-1 Female business Proinsulin medicine.drug |
| Zdroj: | Journal of Internal Medicine. 258:13-20 |
| ISSN: | 1365-2796 0954-6820 |
| Popis: | To explore the role of tissue plasminogen activator (tPA) activity and plasminogen activator inhibitor type 1 (PAI-1) in survivors of a first myocardial infarction (MI). Insulin and proinsulin were analysed as potential risk factors.Case-control study in northern Sweden.A total of 115 patients under 65 years of age with a first MI were enrolled and recalled for further examination 3 months later. Twenty-seven patients were excluded, 17 with known diabetes and 10 who did not come to the follow-up, giving a final number of 88 patients, 73 men and 15 women. Patients were age- and sex-matched with control subjects drawn from the local cohort in the MONICA population survey 1994.We compared MI patients and controls using univariate and multiple regression analyses including odds ratios (OR).PAI-1 activity, fibrinogen, postload insulin and -proinsulin were significantly higher and tPA activity significantly lower in MI patients in the univariate analysis. In a multiple regression analysis, including also age, sex and cardiovascular risk factors, these parameters were divided in quartiles. The lowest quartile of tPA activity was significantly associated with MI (OR = 19.1; CI 3.0-123) together with the highest quartiles of fibrinogen (OR = 25; CI 5.2-120) but other variables were not.Low tPA activity, i.e. low fibrinolytic activity, characterized nondiabetic subjects after a first MI which is not explained by concomitant disturbances in metabolic and anthropometric variables. |
| Databáze: | OpenAIRE |
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