| Autor: |
Christophe Ferrand, Marina Deschamps, Olivier Adotevi, Sebastien Tabruyn, Francine Garnache-Ottou, Etienne Daguindau, Sabeha Biichle, Severine Valmary-Degano, Marius Moldovan, Denis Caillot, Cyril Faure, Ziad Fajloun, Eric Deconinck, Rim Trad, Mathieu Neto Da Rocha, Fabrice Larosa, Walid Warda |
| Rok vydání: |
2023 |
| DOI: |
10.1158/0008-5472.22421867 |
| Popis: |
Figure S1. In vitro detection (using #A3C3) of recombinant IL-1RAP protein by ELISA Figure S2. Procedure for generating IL-1RAP CART cells and CD4/CD8 ratio at the end of the process Figure S3. Staining of IL-1RAP CAR at the cell surface of T cell line or primary T -lymphocytes Figure S4. Impact of the IL-1RAP soluble form on IL-1RAP CART-cells toxicity Figure S5. Tissue macroarray (TMA) using #A3C3 monoclonal antibody Figure S6. Experimental immunosafety human CD34+ engrafted NOG murine model Figure S7. Colony Forming Unit (CFU-GM) experiment after coculture of autologous CART-cells with CD34+ HSC. Figure S8. In-vitro and in-vivo iCASP/AP1903 suicide gene safety switch Figure S9. Production and characterization of IL-1RAP (soluble and membrane) transfected cell line Figure S10. Cytokine secretion profiling of IL-1RAP CART-cells after co-culturing with targets Figure S11. Tumoral xenograft murine model Figure S12. Autologous cytotoxicity of IL-1RAP CART-cells directed against initial CML disease |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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