Preparation and Properties of Oligodeoxynucleotides Containing 5-Iodouracil and 5-Bromo- and 5-Iodocytosine
| Autor: | Christoph W. Müller, Ramon Eritja, Marten Wiersma, Elisenda Ferrer, Bernard Kazimierczak |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Pharmacology
5-iodocytosine Oligonucleotide Chemistry Organic Chemistry Oligonucleotides Temperature Biomedical Engineering Pharmaceutical Science Bioengineering Cytosine Ammonia chemistry.chemical_compound X-Ray Diffraction Organic chemistry Spectrophotometry Ultraviolet Crystallization Uracil 5-Iodouracil Chromatography High Pressure Liquid Biotechnology Triple helix |
| Zdroj: | Bioconjugate Chemistry. 8:757-761 |
| ISSN: | 1520-4812 1043-1802 |
| Popis: | The behavior of oligonucleotides containing 5-iodouracil, 5-bromocytidine, and 5-iodocytidine in concentrated ammonia is described. 5-Aminouracil and 5-aminocytidine are obtained as side products when deprotection is performed at 60 degrees C. Small amounts, if any, of side products are obtained when ammonia deprotection is performed at room temperature. The base-pairing properties of these 5-halopyrimidines including triple helix are described. |
| Databáze: | OpenAIRE |
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