Synthesis and Antituberculosis Activity of New Hydrazide Derivatives
| Autor: | Gülhan Turan-Zitouni, Jean-Claude Teulade, Ahmet Özdemir, Zafer Asım Kaplancıklı |
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| Přispěvatelé: | Anadolu Üniversitesi, Eczacılık Fakültesi, Farmasötik Kimya Anabilim Dalı, Kaplancıklı, Zafer Asım, Turan, Gülhan, Özdemir, Ahmet |
| Rok vydání: | 2008 |
| Předmět: |
Pyridines
medicine.drug_class Antitubercular Agents Carboxylic Acids Pharmaceutical Science Microbial Sensitivity Tests Hydrazide Antimycobacterial Mycobacterium tuberculosis Structure-Activity Relationship chemistry.chemical_compound Acetic acid Imidazo[1 2-A]Pyridine Sulfanyl Drug Discovery Pyridine medicine Structure–activity relationship Organic chemistry Antituberculosis Activity Molecular Structure biology Spectrum Analysis Broth microdilution biology.organism_classification Hydrazines chemistry Benzaldehydes Nuclear chemistry |
| Zdroj: | Archiv der Pharmazie. 341:721-724 |
| ISSN: | 1521-4184 0365-6233 |
| Popis: | WOS: 000261440800007 PubMed ID: 18720343 The increasing clinical importance of drug-resistant mycobacterial pathogens, especially Mycobacterium tuberculosis, has lent additional urgency to microbiological research and new antimycobacterial compound development. For this purpose, new hydrazide derivatives of imidazo[1,2-a]pyridine were synthesized and evaluated for antituberculosis activity. The reaction of 2-[(2-carboxyimidazo[1,2-a]pyridine-3-yl)sulfanyl]acetic acid hydrazide with various benzaldehydes gave N-(arylidene)-2-[(2-carboxyimidazo[1,2-a]pyridine-3-yl)sulfanyl]acetic acid hydrazide derivatives. The chemical structures of the compounds were elucidated by IR, H-1-NMR, FAB-MS spectral data and elemental analysis. Anti tuberculosis activities of the synthesized compounds were determined by broth microdilution assay, the Microplate Alamar Blue Assay in BACTEC 12B medium. The results were screened in vitro, using the BACTEC 460 Radiometric System against Mycobacterium tuberculosis H37Rv (ATCC 27294) at 6.25 mu g/mL; the tested compounds showed significant inhibition. |
| Databáze: | OpenAIRE |
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