Endothelial function and arterial stiffness indexes in subjects with acute ischemic stroke: Relationship with TOAST subtype
| Autor: | Carlo Maida, Alessandra Casuccio, Antonio Pinto, Valerio Vassallo, Rosaria Pecoraro, Irene Simonetta, Antonino Tuttolomondo, Vittoriano Della Corte, Domenico Di Raimondo, Valentina Arnao |
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| Přispěvatelé: | Tuttolomondo A, Casuccio A, Della Corte V, Maida C, Pecoraro R, Di Raimondo D, Vassallo V, Simonetta I, Arnao V, Pinto A. |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Male
Settore MED/09 - Medicina Interna Subtype 030204 cardiovascular system & hematology Brain Ischemia 0302 clinical medicine Risk Factors Ischemic Odds Ratio Medicine Endothelial dysfunction Acute ischemic stroke Pulse wave velocity Stroke Stiffness Subtypes TOAST Aged 80 and over Middle Aged Peripheral Cardiology Female Cardiology and Cardiovascular Medicine medicine.medical_specialty Manometry Hyperemia Pulse Wave Analysis 03 medical and health sciences Vascular Stiffness Predictive Value of Tests medicine.artery Internal medicine Humans cardiovascular diseases Radial artery Reactive hyperemia Aged Chi-Square Distribution business.industry medicine.disease Surgery body regions Logistic Models Case-Control Studies Multivariate Analysis Arterial stiffness Stiffne Endothelium Vascular business 030217 neurology & neurosurgery |
| Popis: | Background and aims Only one study has examined endothelial function in subjects with acute ischemic stroke and no study has yet assessed arterial stiffness and reactive hyperemia peripheral arterial tonometry (RH-PAT) in ischemic stroke and its clinical subtypes. Our study aimed to evaluate arterial stiffness and endothelial dysfunction indexes in patients with acute ischemic stroke and the relationship between endothelial dysfunction indexes and arterial stiffness markers and stroke subtypes according to Trial of Org 10172 in Acute Stroke Treatment (TOAST) Classification. Methods We enrolled 98 patients with a diagnosis of acute ischemic stroke and 105 hospitalized patients without a diagnosis of acute ischemic stroke. Arterial stiffness analysis was conducted by applanation tonometry to record radial artery pressure waveform continuously; augmentation index (Aix) and pulse wave velocity (PWV) were calculated. The reactive hyperemia index (RHI) was assessed by peripheral arterial tonometry. Results In comparison to controls, ischemic stroke subjects had higher mean levels of PWV, Aix, and significantly lower mean RHI values. Compared to subjects with lacunar and cardioembolic stroke, those with Large Artery AtheroSclerosis (LAAS) subtype of stroke had higher median levels of PWV and significantly lower median levels of RHI. On multinomial logistic regression analysis of predictive variables of stroke subtype (lacunar vs. LAAS and lacunar vs. cardioembolic), we observed a negative association between RHI value and LAAS subtype and a negative association of PWV with cardioembolic subtype. Conclusions Our findings underline the relationship between endothelial and arterial stiffness index correlations in patients with acute ischemic stroke, also suggesting the use of a combination of PAT and arterial stiffness indexes to better categorize patients with ischemic stroke. |
| Databáze: | OpenAIRE |
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