Osteoporotic fractures in rheumatoid arthritis patients in Argentina: a matched retrospective cohort study
| Autor: | Martin Brom, Javier Rosa, Valeria Scaglioni, Enrique R. Soriano, Florencia S. Pierini, Marina Scolnik |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
lcsh:Immunologic diseases. Allergy
medicine.medical_specialty lcsh:Diseases of the musculoskeletal system Osteoporosis 030209 endocrinology & metabolism 03 medical and health sciences 0302 clinical medicine Rheumatology Internal medicine medicine In patient Rheumatoid arthritis Glucocorticoids 030203 arthritis & rheumatology Proportional hazards model business.industry Incidence (epidemiology) Incidence Retrospective cohort study medicine.disease University hospital lcsh:RC925-935 business Fragility fractures lcsh:RC581-607 |
| Zdroj: | Advances in Rheumatology, Vol 61, Iss 1, Pp 1-7 (2021) |
| ISSN: | 2523-3106 |
| Popis: | Background To compare the incidence of osteoporotic fractures in patients with rheumatoid arthritis (RA) with matched controls from a university hospital. Methods Consecutive RA patients (n = 100) were matched (age and sex) with controls (1:2). The follow-up period began at the index date, defined as the date of diagnosis for RA patients and the date of the first medical claim at the Health Management Organization (HMO) for non-RA patients. Fracture incidence rates per 1000 persons-years (PY) for distinct types of fractures were calculated. Multivariate cox regression analysis was performed to identify factors associated with fractures. Results One hundred RA patients were followed for a total of 975.1 patients-years and 200 controls for 1485.7 patients-years. No difference was found in the overall fracture incidence rate per 1000 PY between RA and controls (19.5, 95% CI 12.7–28.6 vs 12.1, 95% CI 7.7–18.7, p = 0.07). In the Cox regression analysis, only age (HR 1.06, 95% CI 1.02–1.11, p = 0.006) and history of a prior fracture (HR 9.85, 95% CI 2.97–32.64, p p = 0.01). Conclusion Patients with RA didn’t show an overall increased risk of osteoporotic fractures compared with matched controls, but vertebral fractures were more frequently observed in patients with RA. |
| Databáze: | OpenAIRE |
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