Exploring variations in ovarian cancer survival by age and stage (ICBP SurvMark-2): A population-based study
| Autor: | Charles H Norell, Isabelle Soerjomataram, Lorraine Shack, Freddie Bray, Jacques Ferlay, Paul A. Cohen, Prithwish De, Bjørn Møller, Richard Trevithick, Paul M. Walsh, Brian Rous, Hanna E. Tervonen, Alon D. Altman, Samantha Harrison, Peter Sykes, Eileen Morgan, Gerda Engholm, Geoff Porter, Dianne L. O'Connell, Michael Eden, Citadel J Cabasag, Andy Nordin, Serena Kozie, Mark J. Rutherford, Sarah E. Ferguson, Aude Bardot, Anna Gavin, Janice S. Kwon, Melina Arnold, John Butler, Louise Hanna, Nathalie Saint-Jacques |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
0301 basic medicine Canada Adolescent Population Carcinoma Ovarian Epithelial Young Adult 03 medical and health sciences 0302 clinical medicine SDG 3 - Good Health and Well-being Advanced disease Humans Medicine Neoplasm Invasiveness Registries Stage (cooking) education Net Survival Aged Neoplasm Staging Aged 80 and over Ovarian Neoplasms education.field_of_study Norway business.industry Age Factors Australia Obstetrics and Gynecology Cancer Middle Aged medicine.disease United Kingdom Population based study 030104 developmental biology Oncology 030220 oncology & carcinogenesis Period Analysis Female business Ovarian cancer Ireland New Zealand Demography |
| Zdroj: | Cabasag, C J, Butler, J, Arnold, M, Rutherford, M, Bardot, A, Ferlay, J, Morgan, E, Møller, B, Gavin, A, Norell, C H, Harrison, S, Saint-Jacques, N, Eden, M, Rous, B, Nordin, A, Hanna, L, Kwon, J, Cohen, P A, Altman, A D, Shack, L, Kozie, S, Engholm, G, De, P, Sykes, P, Porter, G, Ferguson, S, Walsh, P, Trevithick, R, O'Connell, D, Bray, F & Soerjomataram, I 2020, ' Exploring variations in ovarian cancer survival by age and stage (ICBP SurvMark-2) : A population-based study ', Gynecologic Oncology . https://doi.org/10.1016/j.ygyno.2019.12.047 |
| ISSN: | 0090-8258 |
| Popis: | OBJECTIVE: The study aims to evaluate the differences in ovarian cancer survival by age and stage at diagnosis within and across seven high-income countries.METHODS: We analyzed data from 58,161 women diagnosed with ovarian cancer during 2010-2014, followed until 31 December 2015, from 21 population-based cancer registries in Australia, Canada, Denmark, Ireland, New Zealand, Norway, and United Kingdom. Comparisons of 1-year and 3-year age- and stage-specific net survival (NS) between countries were performed using the period analysis approach.RESULTS: Minor variation in the stage distribution was observed between countries, with most women being diagnosed with 'distant' stage (ranging between 64% in Canada and 71% in Norway). The 3-year all-ages NS ranged from 45 to 57% with Australia (56%) and Norway (57%) demonstrating the highest survival. The proportion of women with 'distant' stage was highest for those aged 65-74 and 75-99 years and varied markedly between countries (range:72-80% and 77-87%, respectively). The oldest age group had the lowest 3-year age-specific survival (20-34%), and women aged 65-74 exhibited the widest variation across countries (3-year NS range: 40-60%). Differences in survival between countries were particularly stark for the oldest age group with 'distant' stage (3-year NS range: 12% in Ireland to 24% in Norway).CONCLUSIONS: International variations in ovarian cancer survival by stage exist with the largest differences observed in the oldest age group with advanced disease. This finding endorses further research investigating international differences in access to and quality of treatment, and prevalence of comorbid conditions particularly in older women with advanced disease. |
| Databáze: | OpenAIRE |
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