Cure of Limb-Threatening XDR Pseudomonas aeruginosa Infection: Combining Genome Sequencing, Therapeutic Drug Level Monitoring, and Surgical Debridement

Autor:	Roger L. Nation, Jason C Kwong, Natasha E Holmes, Shanti Narayanasamy, M Lindsay Grayson, Norelle L Sherry, Andrew G. Ellis, Andrew A Mahony, Sharmila Khumra, Albert G Frauman
Rok vydání:	2020
Předmět:	0301 basic medicine medicine.medical_specialty therapeutic drug monitoring medicine.medical_treatment 030106 microbiology XDR gram-negative Fosfomycin medicine.disease_cause 03 medical and health sciences 0302 clinical medicine medicine Novel ID Cases colistin 030212 general & internal medicine fosfomycin Debridement medicine.diagnostic_test business.industry Pseudomonas aeruginosa Osteomyelitis Therapeutic drug level Surgical debridement osteomyelitis biochemical phenomena metabolism and nutrition medicine.disease Surgery AcademicSubjects/MED00290 Infectious Diseases Oncology Therapeutic drug monitoring Colistin business medicine.drug
Zdroj:	Open Forum Infectious Diseases
ISSN:	2328-8957
DOI:	10.1093/ofid/ofaa572
Popis:	We describe a case of limb-threatening osteomyelitis and metalware infection with carbapenemase-producing extensively drug-resistant Pseudomonas aeruginosa successfully cured with aggressive surgical debridement and combined intravenous fosfomycin and colistin. Real-time therapeutic drug monitoring was used to maximize probability of efficacy and minimize potential for toxicity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8d6158cb3d253d372b41dfd7a59a7c4 https://doi.org/10.1093/ofid/ofaa572 Zobrazit plný text záznamu