Study of serum YKL-40 in children with bronchial asthma
| Autor: | Iman A. Mohammed, Wael A. Shalaby, Safia M Diab, Doaa R. Soliman |
|---|---|
| Jazyk: | angličtina |
| Předmět: |
musculoskeletal diseases
medicine.medical_specialty YKL-40 Exacerbation Asthma severity Gastroenterology Severity 03 medical and health sciences 0302 clinical medicine Internal medicine medicine In patient 030212 general & internal medicine Asthma business.industry Protein level Biomarker medicine.disease Asthmatic children 030228 respiratory system Physical therapy Blood eosinophils Biomarker (medicine) (Chitinase-3-like-1) business |
| Zdroj: | Egyptian Pediatric Association Gazette. (1):26-31 |
| ISSN: | 1110-6638 |
| DOI: | 10.1016/j.epag.2015.11.003 |
| Popis: | BackgroundSerum YKL-40 (chitinase-3-like-1) has recently been found to be either the cause or a biomarker for asthma. This study quantifies serum levels of YKL-40 in asthmatic children and evaluates the relationship between YKL-40 and asthma severity.MethodsWe quantified serum YKL-40 levels in two groups of asthmatic children (aged between 2 and 12years). Group 1 (n: 30) in between the attack (stable group) and group 2 (n: 30) during the exacerbation (acute attack group). Serum YKL-40 was measured by enzyme-linked immunosorbent assay (ELIZA) Kits (WKEA MED SUPPLIES CORP). We measured blood eosinophils and peak expiratory flow rate for children >5years.ResultsSerum levels of YKL-40 were significantly elevated in the acute asthma group and in the stable asthma group compared to the control group (673.92±24.23ng/ml, 552.73±57.34ng/ml, 136.17±53.14) respectively, P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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