Targeting Pain-evoking Transient Receptor Potential Channels for the Treatment of Pain
| Autor: | Susan M. Carlton, Edgar T. Walters, Hongzhen Hu, Jialie Luo |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Inflammation
Bioinformatics 01 natural sciences Article 03 medical and health sciences Transient receptor potential channel 0302 clinical medicine Medicine pain Pharmacology (medical) drug target Sensitization Pharmacology Neurogenic inflammation 010405 organic chemistry business.industry Chronic pain Visceral pain General Medicine medicine.disease 3. Good health 0104 chemical sciences Psychiatry and Mental health medicine.anatomical_structure pain management Neurology inflammation Neuropathic pain Nociceptor neuropathy Neurology (clinical) medicine.symptom business Transient receptor potential channels 030217 neurology & neurosurgery |
| Zdroj: | Current Neuropharmacology |
| ISSN: | 1570-159X |
| DOI: | 10.2174/1570159x113119990040 |
| Popis: | Chronic pain affects billions of lives globally and is a major public health problem in the United States. However, pain management is still a challenging task due to a lack of understanding of the fundamental mechanisms of pain. In the past decades transient receptor potential (TRP) channels have been identified as molecular sensors of tissue damage and inflammation. Activation/sensitization of TRP channels in peripheral nociceptors produces neurogenic inflammation and contributes to both somatic and visceral pain. Pharmacological and genetic studies have affirmed the role of TRP channels in multiple forms of inflammatory and neuropathic pain. Thus pain-evoking TRP channels emerge as promising therapeutic targets for a wide variety of pain and inflammatory conditions. |
| Databáze: | OpenAIRE |
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