Natriuretic peptide receptor a promotes gastric malignancy through angiogenesis process
| Autor: | Zheng Li, Zhe Xuan, Jialun Lv, Guangli Sun, Hao Xu, Diancai Zhang, Hao Fan, Zekuan Xu, Jiacheng Cao, Linjun Wang, Yiwen Xia, Sen Wang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Vascular Endothelial Growth Factor A
CD31 Cancer Research Angiogenesis Proteolysis Immunology Mice Nude Models Biological Article Metastasis Cellular and Molecular Neuroscience Stomach Neoplasms In vivo Cell Line Tumor Human Umbilical Vein Endothelial Cells Animals Humans Medicine Gene Silencing Cell Proliferation Neoplasm Staging Neovascularization Pathologic medicine.diagnostic_test QH573-671 business.industry Cancer Cell Biology Hypoxia-Inducible Factor 1 alpha Subunit Prognosis medicine.disease Xenograft Model Antitumor Assays Up-Regulation Gene Expression Regulation Neoplastic Disease Models Animal Tumor progression Cancer research Immunohistochemistry Female Gastric cancer business Cytology Receptors Atrial Natriuretic Factor Signal Transduction |
| Zdroj: | Cell Death and Disease, Vol 12, Iss 11, Pp 1-11 (2021) Cell Death & Disease |
| ISSN: | 2041-4889 |
| Popis: | Gastric cancer (GC) ranks the third among global cancer-related mortality, especially in East Asia. Angiogenesis plays an important role in promoting tumor progression, and clinical trials have demonstrated that anti-angiogenesis therapy is effective in GC management. Natriuretic peptide receptor A (NPRA) functions significantly in promoting GC development and progression. Whether NPRA can promote angiogenesis of GC remains unclear. Tumor samples collection and immunohistochemical experiment showed that the expression of NPRA was positively correlated with the expression of CD31 and vessel density. In vivo and in vitro analysis showed that NPRA could promote GC-associated angiogenesis and tumor metastasis. Results of Co-IP/MS showed that NPRA could prevent HIF-1α from being degraded by binding to HIF-1α. Protection of HIF-1α improved VEGF levels and thus promoted angiogenesis. In summary, NPRA protected HIF-1α from proteolysis by binding to HIF-1α, increased the expression of HIF-1α, and promoted GC angiogenesis. This study has discovered a new mechanism for NPRA to promote gastric cancer development and a new regulatory mechanism for HIF-1α. |
| Databáze: | OpenAIRE |
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