Orally Administered Activated Charcoal as a Medical Countermeasure for Acute Radiation Syndrome in Rats

Autor: Olga V. Yurchenko, Mo Alavijeh, Joaquín Silvestre-Albero, E.A. Snezhkova, Natalia Rodionova, Natalia Riabchenko, Marharyta Pakharenko, Nikolaev Vladimir G, Alexey Sydorenko, Dennis Bilko, Kvitoslava Bardakhivska
Přispěvatelé: Universidad de Alicante. Departamento de Química Inorgánica, Universidad de Alicante. Instituto Universitario de Materiales, Materiales Avanzados
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Acute radiation sickness
Endogeny
Pharmacology
lcsh:Technology
lcsh:Chemistry
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
White blood cell
medicine
General Materials Science
activated charcoal
Instrumentation
lcsh:QH301-705.5
030304 developmental biology
Fluid Flow and Transfer Processes
Química Inorgánica
0303 health sciences
business.industry
Superoxide
lcsh:T
Process Chemistry and Technology
General Engineering
Acute Radiation Syndrome
acute radiation sickness
medicine.disease
Small intestine
lcsh:QC1-999
Rats
3. Good health
Computer Science Applications
rats
medicine.anatomical_structure
Activated charcoal
chemistry
lcsh:Biology (General)
lcsh:QD1-999
lcsh:TA1-2040
030220 oncology & carcinogenesis
Radiation sickness
enterosorbent
Enterosorbent
Bone marrow
business
lcsh:Engineering (General). Civil engineering (General)
lcsh:Physics
Zdroj: Applied Sciences, Vol 11, Iss 3174, p 3174 (2021)
RUA. Repositorio Institucional de la Universidad de Alicante
Universidad de Alicante (UA)
Applied Sciences
Volume 11
Issue 7
ISSN: 2076-3417
Popis: Activated charcoal (AC) can be taken orally as enterosorbent for treatment of pathological states related to exogenous and endogenous intoxications. Synthesized granulated AC with a highly developed active surface (SBET ~2700 m2/g) was used as a medical countermeasure (MCM) to acute radiation sickness (ARS) in rats after total body X-ray irradiation. AC demonstrates positive results in ARS treatment, as expressed in, (i) a decrease in body weight loss, (ii) a protection of bone marrow (BM) cells colony formation capacity, (iii) a reduction of BM chromosomal aberrations and small intestine and spleen tissue damage, (iv) an amelioration of white blood cell count, and (v) a mitigation of superoxide ion generation rate in the liver. AC oral prescription seems to be perspective modality of ARS treatment. This research was funded by H2020-MSCA-RISE-2016 project, grant number 734641 acronym NanoMed.
Databáze: OpenAIRE
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