Investigation of antioxidant and anti-inflammatory activities as well as the renal protective potential of green coffee extract in high fat-diet/streptozotocin-induced diabetes in male albino rats
| Autor: | Doaa M Abdel-Mohsen, Ahmed M. A. Akabawy, Ohoud D. AlAmri, Rasha S. Albeltagy, Shahenda Mahgoub, Ahmed E. Abdel Moneim, Hatem K. Amin |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Antioxidant medicine.drug_class medicine.medical_treatment Medicine (miscellaneous) Apoptosis Type 2 diabetes Anti-inflammatory 03 medical and health sciences chemistry.chemical_compound 0404 agricultural biotechnology STZ Diabetes mellitus Internal medicine medicine TX341-641 Green coffee Inflammation 030109 nutrition & dietetics Nutrition and Dietetics Aldosterone business.industry Nutrition. Foods and food supply 04 agricultural and veterinary sciences medicine.disease Streptozotocin 040401 food science Endocrinology High-fat diet chemistry Green coffee extract Metabolic syndrome business Food Science medicine.drug Renal function |
| Zdroj: | Journal of Functional Foods, Vol 71, Iss, Pp 103996-(2020) |
| ISSN: | 1756-4646 |
| Popis: | Green coffee consumption has been stated to have a converse association with type 2 diabetes and metabolic syndrome. Hence, we assessed changes produced by the administration of different doses of green coffee on biomarkers related to renal and antioxidant systems. The study was carried out on 42 diabetic male albino rats; a high-fat diet (HFD) and a single dose of streptozotocin (STZ; 35 mg kg−1) were utilized for model induction. Diabetic rats were received green coffee water extract (GCWE; 50 and 100 mg kg−1) daily for 28 days. GCWE caused a remarkable recovery of kidney weight, kidney function, and aldosterone level, particularly. Proapoptotic, antiapoptotic and inflammatory markers were significantly improved and showing a great retain to their normal levels specifically in GCWE-treated groups. Also, a marked improvement in the antioxidants defense system was noted. GCWE has a great protective influence on kidney injury of HFD/STZ‐induced diabetic rats. |
| Databáze: | OpenAIRE |
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