Phytochemical constituents and biological activities of Cleome iberica DC
| Autor: | Mahdi Moridi Farimani, Maryam Akhbari, Arezoo Rustaie, Emad Nazarianpoor |
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| Rok vydání: | 2016 |
| Předmět: |
DPPH
Phytochemicals Flavonoid Plant Science 01 natural sciences Biochemistry Antioxidants Analytical Chemistry HeLa chemistry.chemical_compound Anti-Infective Agents Phenols Humans Cleome MTT assay Lupeol Flavonoids chemistry.chemical_classification Cell Death biology Traditional medicine Plant Extracts 010405 organic chemistry Chemistry Organic Chemistry Plant Components Aerial biology.organism_classification Daucosterol Antineoplastic Agents Phytogenic Triterpenes 0104 chemical sciences 010404 medicinal & biomolecular chemistry Phytochemical HeLa Cells |
| DOI: | 10.6084/m9.figshare.4010694.v1 |
| Popis: | Phytochemical investigation of Cleome iberica DC. aerial parts led to the isolation and characterisation of six triterpenoid including glutinol (1), lupeol (2), β-sitosterol (3), cabraleadiol monoacetate (4), cabraleadiol (6) and daucosterol (8), one flavonoid, calycopterin (5) along with a fatty acid, tricosanoic acid (7). While studied samples showed weak potency in antimicrobial assessment, the acetone extract and some isolated compounds exhibited considerable cytotoxicity against cervical cancer cell line (HeLa) in MTT assay, among them calycopterin with IC50 equals to 5.1 μM was the strongest. The extract showed moderate antioxidant capacity in DPPH assay method (IC50 = 100.2 μg/mL) and total phenolics and total flavonoids contents of the dried extract were also determined as 39.6 and 90.7 mg/g, respectively. |
| Databáze: | OpenAIRE |
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