The prognostic implication of visual acuity at the time of uveal melanoma diagnosis

Autor: Elin Asplund, Maria Fili, Tony Pansell, Rune Brautaset, Maria Nilsson, Gustav Stålhammar
Rok vydání: 2022
Předmět:
Zdroj: Eye.
ISSN: 1476-5454
0950-222X
DOI: 10.1038/s41433-022-02316-8
Popis: Background Visual outcomes after primary tumour treatment of uveal melanoma (UM) have been investigated repeatedly. This study evaluates the correlation between best-corrected visual acuity (BCVA) before treatment with clinicopathological factors and patient survival. Subjects/Methods Pre-treatment BCVA was examined in relation to tumour dimensions and location, and survival in a retrospective cohort of 1809 patients who underwent plaque brachytherapy. BCVA was also correlated to tumour histological factors in a second cohort of 137 enucleated eyes. Results The mean BCVA of the tumour eye prior to plaque brachytherapy was LogMAR 0.42 (SD 0.46). Patients with low BCVA (LogMAR ≥ 1.00) did not differ in age (p = 0.19) and had similar frequency of ciliary body involvement (p = 0.99) but had tumours with greater apical thickness (p p p p > 0.004). Patients with low BCVA had greater incidence of UM-related mortality in competing risk analysis (p = 0.0019) and shorter overall survival (p Conclusions UM patients with low BCVA before primary tumour treatment have a worse prognosis, likely related to increased tumour dimensions. Future studies should examine the prognostic significance of BCVA in relation to macula-involving retinal detachment and genetic factors.
Databáze: OpenAIRE
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