Interstrain Variations in the Cytomegalovirus (CMV) Glycoprotein B Gene Sequence among CMV-Infected Children Attending Six Day Care Centers
| Autor: | Jeanne Boucher, Paul Dény, Jean-Claude Nicolas, Philippe Reinert, Catherine Asselot, Monique Rauzy, Serge Lasry, Chantal Guyot, Alain Livartowski, Marie-Claude Leroux |
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| Rok vydání: | 1996 |
| Předmět: |
Human cytomegalovirus
Molecular Sequence Data Congenital cytomegalovirus infection Cytomegalovirus medicine.disease_cause Polymerase Chain Reaction Vial Herpesviridae Virus Viral Envelope Proteins Betaherpesvirinae medicine Humans Immunology and Allergy Base Sequence biology Infant Newborn Genetic Variation Infant Sequence Analysis DNA medicine.disease biology.organism_classification Virology Infectious Diseases Cytomegalovirus Infections Immunology Coinfection Viral disease |
| Zdroj: | Journal of Infectious Diseases. 174:606-609 |
| ISSN: | 1537-6613 0022-1899 |
| DOI: | 10.1093/infdis/174.3.606 |
| Popis: | Using the shell vial assay and sequence analysis of a variable region of the glycoprotein B (gB) gene, cytomegalovirus (CMV) excretion rates in urine and virus transmission were studied among 93 children from six day care centers (DCCs). During a 6-month period, excretion rates differed significantly between DCCs (P < .001). The 6 gB gene sequences, obtained from 24 CMV-infected children, were classified in four previously defined groups. In five DCCs, 2 or 3 strains cocirculated, and none was dominant. Infection could have been acquired outside the DCC for 2 children and inside it for 9. Two children from the same DCC had mixed infections. No differences in hygiene, child care practices, or experience and level of qualification of the staff could explain this wide variety of excretion rates between DCCs. The distribution of gB gene patterns observed does not suggest that 1 type was dominant or more efficiently transmitted. |
| Databáze: | OpenAIRE |
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