NGS-based typings for 7 HLA loci in two populations from Barra Mansa, RJ, Brazil
| Autor: | Romulo Vianna, Juliana Fernandes Cardoso, Luís Cristóvão Porto, Leonardo Hanhoerderster |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Linkage disequilibrium Immunology Frequency data Locus (genetics) Human leukocyte antigen Biology Linkage Disequilibrium 03 medical and health sciences 0302 clinical medicine Gene Frequency Population Groups Genotype Immunology and Allergy Humans Typing Allele Allele frequency Alleles Genetics Histocompatibility Antigens Class I Histocompatibility Antigens Class II High-Throughput Nucleotide Sequencing General Medicine 030104 developmental biology Genetics Population Haplotypes Brazil 030215 immunology |
| Zdroj: | Human immunology. 82(1) |
| ISSN: | 1879-1166 |
| Popis: | We investigated HLA class I (HLA-A, -B, and -C) and class II (HLA-DRB1, -DQB1, -DPA1, and -DPB1) alleles by NGS-based typing among 478 Brazilian individuals from two populations in the Barra Mansa city based on their self-declared skin color (Caucasian, N = 405, AFND-ID: 3729; Black, N = 73, AFND-ID: 3731) to calculate allelic and haplotypic frequencies, plus linkage disequilibrium. No locus deviated from Hardy-Weinberg equilibrium. Both populations shared the most frequent allele on HLA-A, -C, -DPA1, and -DPB1. Genotype and frequency data are available in the Allele Frequencies Net Database. |
| Databáze: | OpenAIRE |
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