Guards of the great wall: bacterial lysozyme inhibitors
| Autor: | Joris M. Van Herreweghe, Arnout Voet, Chris W. Michiels, Lise Vanderkelen, Seppe Leysen, Lien Callewaert |
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| Rok vydání: | 2012 |
| Předmět: |
Models
Molecular Microbiology (medical) Sequence Homology Pseudopeptidoglycan Biology Models Biological Microbiology Bacterial cell structure chemistry.chemical_compound Bacterial Proteins Virology Animals Humans Enzyme Inhibitors Muramidase Phylogeny Innate immune system Bacteria Effector biology.organism_classification Infectious Diseases chemistry Biochemistry Peptidoglycan Lysozyme |
| Zdroj: | Trends in Microbiology. 20:501-510 |
| ISSN: | 0966-842X |
| Popis: | Peptidoglycan is the major structural component of the bacterial cell wall. It provides resistance against turgor and its cleavage by hydrolases such as lysozymes results in bacteriolysis. Most, if not all, animals produce lysozymes as key effectors of their innate immune system. Recently, highly specific bacterial proteinaceous lysozyme inhibitors against the three major animal lysozyme families have been discovered in bacteria, and these may represent a bacterial answer to animal lysozymes. Here, we will review their properties and phylogenetic distribution, present their structure and molecular interaction mechanism with lysozyme, and discuss their possible biological functions and potential applications. |
| Databáze: | OpenAIRE |
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