Changes of cerebrospinal fluid protein concentrations and gait patterns in geriatric normal pressure hydrocephalus patients after ventriculoperitoneal shunting surgery
| Autor: | Jean-Lon Chen, Wan-Ying Lin, Yin-Cheng Huang, Carl P.C. Chen, Chen-Nen Chang, Chih-Chin Hsu |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Male
Proteomics 0301 basic medicine Aging medicine.medical_specialty Taiwan Urinary incontinence Ventriculoperitoneal Shunt Biochemistry 03 medical and health sciences Cognition 0302 clinical medicine Endocrinology Cerebrospinal fluid Normal pressure hydrocephalus Genetics medicine Humans Dementia Electrophoresis Gel Two-Dimensional Molecular Biology Aged Gait Disturbance business.industry Cerebrospinal Fluid Proteins Cell Biology medicine.disease Hydrocephalus Normal Pressure Surgery Shunting Preferred walking speed 030104 developmental biology Gait analysis Regression Analysis Female medicine.symptom Gait Analysis business Biomarkers 030217 neurology & neurosurgery |
| Zdroj: | Experimental Gerontology. 106:109-115 |
| ISSN: | 0531-5565 |
| DOI: | 10.1016/j.exger.2018.01.027 |
| Popis: | Normal pressure hydrocephalus (NPH) was the first type of dementia ever described that can be treated using ventriculoperitoneal shunting surgery. Three typical clinical symptoms of NPH include gait disturbance, progressive cognitive dysfunction, and urinary incontinence. Although there are articles that have discovered several cerebrospinal fluid (CSF) protein biomarkers associated with NPH; however, studies examining individual and total protein concentrations from the ventricular CSF before and after shunting surgery are lacking. This study used proteomics to calculate the CSF individual and total protein concentrations before, and one week, one month and three months after the shunting surgery. Parameters of cadence, step length, walking speed, and percentages of single- and double-limb support in a gait cycle were measured. Protein concentrations associated with anti-oxidation, aging, and in the prevention of neurotoxic agent production increased by at least 2-folds after the surgery, indicating that the brain may become less susceptible to neurodegeneration. These proteins were alpha-1B-glycoprotein, apolipoproteins A-1 & A-IV, prostaglandin-H2 D-isomerase, alpha-1-antitrypsin, and serotransferrin. In gait analysis, lower cadence, decreased double-limb support, longer step length, and increased single-limb support were observed after the surgery, indicating a more stable walking balance. These changes lasted for a period of at least 3 months. As a result, shunting surgery may be recommended for geriatric patients with confirmed diagnosis of normal pressure hydrocephalus. |
| Databáze: | OpenAIRE |
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