Products of Oxidative Guanine Damage Form Base Pairs with Guanine
| Autor: | Katsuhito Kino, Taishu Kawada, Masayo Hirao-Suzuki, Hiroshi Miyazawa, Masayuki Morikawa |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Guanine DNA damage Base pair Stereochemistry G-C transversions Review Catalysis Inorganic Chemistry lcsh:Chemistry Betacoronavirus 03 medical and health sciences chemistry.chemical_compound RNA polymerase base pair Animals Humans Point Mutation Physical and Theoretical Chemistry Base Pairing Molecular Biology lcsh:QH301-705.5 Spectroscopy Triazine 2019 novel coronavirus oxidative guanine damage 030102 biochemistry & molecular biology Chemistry SARS-CoV-2 Point mutation Organic Chemistry RNA General Medicine Ribonucleoside Computer Science Applications 030104 developmental biology lcsh:Biology (General) lcsh:QD1-999 Oxidation-Reduction base incorporation DNA Damage |
| Zdroj: | International Journal of Molecular Sciences, Vol 21, Iss 7645, p 7645 (2020) International Journal of Molecular Sciences |
| ISSN: | 1661-6596 1422-0067 |
| Popis: | Among the natural bases, guanine is the most oxidizable base. The damage caused by oxidation of guanine, commonly referred to as oxidative guanine damage, results in the formation of several products, including 2,5-diamino-4H-imidazol-4-one (Iz), 2,2,4-triamino-5(2H)-oxazolone (Oz), guanidinoformimine (Gf), guanidinohydantoin/iminoallantoin (Gh/Ia), spiroiminodihydantoin (Sp), 5-carboxamido-5-formamido-2-iminohydantoin (2Ih), urea (Ua), 5-guanidino-4-nitroimidazole (NI), spirodi(iminohydantoin) (5-Si and 8-Si), triazine, the M+7 product, other products by peroxynitrite, alkylated guanines, and 8,5′-cyclo-2′-deoxyguanosine (cG). Herein, we summarize the present knowledge about base pairs containing the products of oxidative guanine damage and guanine. Of these products, Iz is involved in G-C transversions. Oz, Gh/Ia, and Sp form preferably Oz:G, Gh/Ia:G, and Sp:G base pairs in some cases. An involvement of Gf, 2Ih, Ua, 5-Si, 8-Si, triazine, the M+7 product, and 4-hydroxy-2,5-dioxo-imidazolidine-4-carboxylic acid (HICA) in G-C transversions requires further experiments. In addition, we describe base pairs that target the RNA-dependent RNA polymerase (RdRp) of RNA viruses and describe implications for the 2019 novel coronavirus (SARS-CoV-2): When products of oxidative guanine damage are adapted for the ribonucleoside analogs, mimics of oxidative guanine damages, which can form base pairs, may become antiviral agents for SARS-CoV-2. |
| Databáze: | OpenAIRE |
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