The various and shared roles of lncRNAs during development
| Autor: | Juan Manuel Murillo-Maldonado, Juan R. Riesgo-Escovar |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Regulation of gene expression Dosage compensation Embryo Nonmammalian Nucleic acid sequence Embryonic Development Gene Expression Regulation Developmental Computational biology Biology Conserved sequence Evolution Molecular 03 medical and health sciences Open reading frame 030104 developmental biology 0302 clinical medicine Animals Drosophila RNA Long Noncoding Homeotic gene Gene 030217 neurology & neurosurgery Developmental Biology Synteny |
| Zdroj: | Developmental dynamics : an official publication of the American Association of AnatomistsREFERENCES. 248(11) |
| ISSN: | 1097-0177 |
| Popis: | lncRNAs, genes transcribed but not translated, longer than 200 nucleotides, are classified as a separate class of nonprotein coding genes. Since their discovery, largely from RNAseq data, a number of pioneer studies have begun to unravel its myriad functions, centered on gene expression regulation, suggesting developmental and evolutionary conservation. Since they do not code for proteins and have no open reading frames, their functional constraints likely differ from that of protein coding genes, or of genes where the majority of the nucleotide sequence is required for function, like tRNAs. This has complicated assessment of both developmental and evolutionary conservation, and the identification of homologs in different species. Here we argue that other characteristics: general synteny and particular chromosomal placement regardless of sequence, sequence micro-motifs, and secondary structure allow for "homologs" to be identified and compared, confirming developmental and evolutionary conservation of lncRNAs. We conclude exemplifying a case in point: that of the evolutionarily conserved lncRNA acal, characterized and required for embryogenesis in Drosophila. |
| Databáze: | OpenAIRE |
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