Perinatal dioxin exposure and neurodevelopment of 2-year-old Vietnamese children in the most contaminated area from Agent Orange in Vietnam
| Autor: | Ngoc Thao Pham, Muneko Nishijo, The Tai Pham, Ngoc Nghi Tran, Van Quan Le, Hai Anh Tran, Huy Anh Vu Phan, Yoshikazu Nishino, Hisao Nishijo |
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| Rok vydání: | 2019 |
| Předmět: |
Male
Polychlorinated Dibenzodioxins Environmental Engineering 010504 meteorology & atmospheric sciences Vietnamese Gross motor skill 010501 environmental sciences Breast milk 01 natural sciences Bayley Scales of Infant Development chemistry.chemical_compound Environmental health Agent Orange Humans Environmental Chemistry Medicine heterocyclic compounds Toddler Waste Management and Disposal Language 0105 earth and related environmental sciences business.industry Environmental Exposure Pollution language.human_language Vietnam chemistry Neurodevelopmental Disorders Child Preschool language Environmental Pollutants Female Environmental Pollution business |
| Zdroj: | Science of The Total Environment. 678:217-226 |
| ISSN: | 0048-9697 |
| DOI: | 10.1016/j.scitotenv.2019.04.425 |
| Popis: | Bien Hoa airbase is the most contaminated area of dioxin contamination from Agent Orange in Vietnam, but little is known about the neurodevelopmental effects of perinatal dioxin exposure on children living nearby. We recruited 210 mother-newborn resident pairs in 2012 and 78 pairs in 2015 and followed them for 2 years to assess the children's neurodevelopment. As a control group, we used 120 mother-child pairs recruited in 2014 in the Ha Dong district of Ha Noi City, an unexposed area. Perinatal dioxin exposure levels were indicated by levels of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and toxic equivalency values of polychlorodibenzodioxins, polychlorodibenzofurans, and nonortho-polychlorinated biphenyls (TEQ-PCDD/Fs/noPCBs) in maternal breast milk. The Bayley Scales of Infant and Toddler Development, Third Edition (Bayley-III) were used to assess neurodevelopment, and scores in each domain were compared between children with different exposure levels using general linear regression models and stratification by sex. Decreased expressive and composite language scores in boys and gross motor scores in girls were found in children exposed to TCDD ≥ 5.5 (pg/g lipid) compared with children with TCDD 1.8. However, in matched pair analysis between children with TCDD ≥ 5.5 and1.8 (pg/g lipid), lower expressive and composite language scores in boys exposed to TCDD ≥ 5.5 were significant, but lower gross motor scores in girls did not reach statistical significance. In addition, significant association was found between levels of PCDD congeners other than TCDD and gross motor scores in boys. These findings suggest that perinatal exposure of TCDD and other PCDD congeners affects development of language and gross motor skills, respectively, in boys at 2 years of age exposed to dioxins originating from Agent Orange in Vietnam. |
| Databáze: | OpenAIRE |
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