Adrenal Tumor Producing 11-Deoxycorticosterone, 18-Hydroxy-11-Deoxycorticosterone and Aldosterone
| Autor: | Masato Kuchii, Hiroki Shima, Akira Baba, Masaaki Umemoto, Shigehiro Tomimoto, Yasuaki Toyoda, Keiji Ueyama, Masato Mizukoshi, Yoshiaki Masuyama, Ichiro Nishio |
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| Rok vydání: | 1996 |
| Předmět: |
Adenoma
medicine.medical_specialty Hydrocortisone Adrenal Gland Neoplasm Adrenal Gland Neoplasms Hypokalemia Adrenocorticotropic hormone chemistry.chemical_compound Internal medicine Renin Renin–angiotensin system Internal Medicine medicine Humans Adrenal adenoma Desoxycorticosterone Aldosterone business.industry General Medicine Middle Aged medicine.disease Endocrinology chemistry Hypertension Female Tomography X-Ray Computed business 11-Deoxycorticosterone 18-Hydroxydesoxycorticosterone medicine.drug |
| Zdroj: | Internal Medicine. 35:123-128 |
| ISSN: | 1349-7235 0918-2918 |
| Popis: | A case of adrenal tumor producing 11-deoxycorticosterone, 18-hydroxy-11-deoxycorticosterone and aldosterone is reported. A 55-year-old woman had hypertension, hypokalemia, low plasma renin activity and an adrenal tumor. The plasma level of aldosterone was normal, and the levels of 11-deoxycorticosterone and 18-hydroxy-11-deoxycorticosterone were extremely high. After the tumor removal, the plasma level of aldosterone decreased and plasma levels of 11-deoxycorticosterone and 18-hydroxy-11-deoxycorticosterone were normalized. The tumor was benign adenoma and the production of steroid hormones was under control of adrenocorticotropic hormone. The enzyme activity of 21-hydroxylation in the tumor was elevated and that of 11 beta-hydroxylation was decreased compared with the adjacent tissue. |
| Databáze: | OpenAIRE |
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