Adrenal Tumor Producing 11-Deoxycorticosterone, 18-Hydroxy-11-Deoxycorticosterone and Aldosterone

Autor: Masato Kuchii, Hiroki Shima, Akira Baba, Masaaki Umemoto, Shigehiro Tomimoto, Yasuaki Toyoda, Keiji Ueyama, Masato Mizukoshi, Yoshiaki Masuyama, Ichiro Nishio
Rok vydání: 1996
Předmět:
Zdroj: Internal Medicine. 35:123-128
ISSN: 1349-7235
0918-2918
Popis: A case of adrenal tumor producing 11-deoxycorticosterone, 18-hydroxy-11-deoxycorticosterone and aldosterone is reported. A 55-year-old woman had hypertension, hypokalemia, low plasma renin activity and an adrenal tumor. The plasma level of aldosterone was normal, and the levels of 11-deoxycorticosterone and 18-hydroxy-11-deoxycorticosterone were extremely high. After the tumor removal, the plasma level of aldosterone decreased and plasma levels of 11-deoxycorticosterone and 18-hydroxy-11-deoxycorticosterone were normalized. The tumor was benign adenoma and the production of steroid hormones was under control of adrenocorticotropic hormone. The enzyme activity of 21-hydroxylation in the tumor was elevated and that of 11 beta-hydroxylation was decreased compared with the adjacent tissue.
Databáze: OpenAIRE