| Autor: |
Hwi Wun Park, Davindra Singh, Maria Concetta Gentile, Elsa Kassardjian, Jonathan Dias, Kiri Stern, M Wyatt Toure, Simran Prasad, Jessica Porras Marroquin, Samantha Sparapani, Allison Wisniewski, Aaliyah Jasmine Weekes, Marion Bardies, Alice Nguyen, Hryssi Krissy Kontos, Margaux Philippon, Ashley Cossitt, Daniella LoScerbo, Emie Dufour, Jocelyn Dault, Charles-Alexandre Plaisir, Nastaran Soroori Motlagh, Nazifa Ali, Flore Maurer, Sarah Trépanier-Chicoine, Christina Kalantzis, Pegah Hadavi, Elie El Haber, Saad Razzaq, Rewaparsad Ramsarun, Damien Robin, Maxim Soroko, Kathy Mu, Sara Kamali, Thivya Iyanker, Isa Davidson, Kahlila Paul-Cole, Claudia Hamel, Zakaria Chihab, Kathy Nguyen-Duong, Ansley Gnanapragasam, Stephanie Tran-Huynh, Samantha Rhainds, Olivia Geraci, Brenton Barrow, Yan Fang Low, Sana Mazhar, Claudia Waddingham, Tamar Kalostian, Danielle Mac Rae, Nargess Farhangdoost, Thi Bich Uyen Le, Joshua Oliver, Tina Daigneault, Chelsea Osborne-Laroche, Elias Gomah, Sajad Soleimani Fard, Chiara Gamberi, Giuliana Biancardi, Emilie Parolin, Anika Forget, Carla Maria Avelar, Laila Toro, Leah Sarah Peer, Alexa Fox, Sabine El-Khoury, Myriam Gebrael, Raminder Bindra, Minky Benedikt, Ryan Scartozzi, Lisa Bui, Cassandra Millet-Boureima, Jeffrey Costa |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Biomedicines, Vol 9, Iss 89, p 89 (2021)
Biomedicines |
| ISSN: |
2227-9059 |
| Popis: |
Vasopressins are evolutionarily conserved peptide hormones. Mammalian vasopressin functions systemically as an antidiuretic and regulator of blood and cardiac flow essential for adapting to terrestrial environments. Moreover, vasopressin acts centrally as a neurohormone involved in social and parental behavior and stress response. Vasopressin synthesis in several cell types, storage in intracellular vesicles, and release in response to physiological stimuli are highly regulated and mediated by three distinct G protein coupled receptors. Other receptors may bind or cross-bind vasopressin. Vasopressin is regulated spatially and temporally through transcriptional and post-transcriptional mechanisms, sex, tissue, and cell-specific receptor expression. Anomalies of vasopressin signaling have been observed in polycystic kidney disease, chronic heart failure, and neuropsychiatric conditions. Growing knowledge of the central biological roles of vasopressin has enabled pharmacological advances to treat these conditions by targeting defective systemic or central pathways utilizing specific agonists and antagonists. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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