Patient-reported health outcomes in long-term lung transplantation survivors: A prospective cohort study

Autor: Rogier A.S. Hoek, Michiel E. Erasmus, Paul F M Krabbe, A Shahabeddin Parizi, Karin M. Vermeulen, Erik A M Verschuuren, J.M. Kwakkel-van Erp, W. van der Bij
Přispěvatelé: Value, Affordability and Sustainability (VALUE), Groningen Institute for Organ Transplantation (GIOT), Pulmonary Medicine
Rok vydání: 2018
Předmět:
Male
Pediatrics
Epidemiology
medicine.medical_treatment
Anxiety
030230 surgery
EMPLOYMENT STATUS
0302 clinical medicine
lung transplantation/pulmonology
Quality of life
QUALITY-OF-LIFE
Immunology and Allergy
Pharmacology (medical)
Longitudinal Studies
Prospective Studies
Survivors
Prospective cohort study
pulmonology
SWEDISH-POPULATION
Depression
Clinical Science
Middle Aged
Prognosis
practice
humanities
FUNCTIONAL STATUS
quality of life (QOL)
Clinical research/practice
HEART
Original Article
Female
epidemiology
medicine.symptom
Adult
medicine.medical_specialty
SEX-DIFFERENCES
Adolescent
Visual analogue scale
Health services and outcomes research
RATING DEPRESSION SCALE
INTERNATIONAL SOCIETY
clinical research/practice
OBSTRUCTIVE PULMONARY-DISEASE
Young Adult
03 medical and health sciences
Qualitative research
lung transplantation
medicine
Humans
Lung transplantation
Patient Reported Outcome Measures
Aged
Transplantation
CYSTIC-FIBROSIS
business.industry
Repeated measures design
health services and outcomes research
Cross-Sectional Studies
Nottingham Health Profile
Quality of life (QOL)
clinical research
030228 respiratory system
Quality of Life
ORIGINAL ARTICLES
Lung transplantation/pulmonology
business
qualitative research
Follow-Up Studies
Zdroj: American Journal of Transplantation, 18(3), 684-695. Wiley
American Journal of Transplantation, 18(3), 684-695. Wiley-Blackwell Publishing Ltd
American Journal of Transplantation
American Journal of Transplantation, 18(3), 684. Blackwell Publishing Asia Pty Ltd
ISSN: 1600-6143
1600-6135
DOI: 10.1111/ajt.14492
Popis: During the last three decades lung transplantation (LTx) has become a proven modality for increasing both survival and health‐related quality of life (HRQoL) in patients with various end‐stage lung diseases. Most previous studies have reported improved HRQoL shortly after LTx. With regard to long‐term effects on HRQoL, however, the evidence is less solid. This prospective cohort study was started with 828 patients who were on the waiting list for LTx. Then, in a longitudinal follow‐up, 370 post‐LTx patients were evaluated annually for up to 15 years. For all wait‐listed and follow‐up patients, the following four HRQoL instruments were administered: State‐Trait Anxiety Inventory, Zung Self‐rating Depression Scale, Nottingham Health Profile, and a visual analogue scale. Cross‐sectional and generalized estimating equation (GEE) analysis for repeated measures were performed to assess changes in HRQoL during follow‐up. After LTx, patients showed improvement in all HRQoL domains except pain, which remained steady throughout the long‐term follow‐up. The level of anxiety and depressive symptoms decreased significantly and remained constant. In conclusion, this study showed that HRQoL improves after LTx and tends to remain relatively constant for the entire life span.
This prospective cohort study follows lung transplant patients up to 15 years after transplantation and shows that health‐related quality of life improves after transplantation and tends to remain relatively constant for the patient's entire life span.
Databáze: OpenAIRE
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