Primary prostate cancer synchronous with renal cell carcinoma: clinical experience and literature review
Autor: | Guo Hao Li, Zhi Shun Wang, Yong Lian Guo, Cheng Cheng Ying, Lin Chen, Zhongyuan Li, Zhi Hua Wan |
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Rok vydání: | 2020 |
Předmět: |
Male
renal cell carcinoma prostate adenocarcinoma Embryology medicine.medical_specialty Prostate biopsy 030232 urology & nephrology Case Report Vimentin Pathology and Forensic Medicine 03 medical and health sciences Prostate cancer 0302 clinical medicine Renal cell carcinoma Prostate Humans Medicine Carcinoma Renal Cell Prostate Acinar Adenocarcinoma medicine.diagnostic_test biology Cluster of differentiation business.industry Prostatic Neoplasms Magnetic resonance imaging Cell Biology General Medicine Middle Aged medicine.disease multiple primary malignancies medicine.anatomical_structure 030220 oncology & carcinogenesis biology.protein Radiology business Developmental Biology |
Zdroj: | Romanian Journal of Morphology and Embryology |
ISSN: | 2066-8279 1220-0522 |
Popis: | The objective of this study was to report the diagnosis and treatment results of primary prostate adenocarcinoma (PRAD) concurrent in a patient with renal cell carcinoma (RCC), and to review the relative literature. A 62-year-old man was admitted to our hospital with chief complaint of a painless, incidentally found renal mass for one year. RCC was initially found by computed tomography (CT) scan, but prostate cancer was incidentally found by abnormal prostate-specific antigen (PSA) level results. The post-nephrectomy pathology assay reported clear RCC with positive staining of vimentin, cluster of differentiation 10 (CD10), carbonic anhydrase IX (CA-IX), paired box 8 (Pax-8), epithelial membrane antigen (EMA), and Ki67 labeling index (Ki67 LI). Magnetic resonance imaging (MRI) revealed uneven signals in the right peripheral zone of the prostate. Both prostate biopsy and post-prostatectomy pathology examination revealed prostate acinar adenocarcinoma with positive staining of P504S and Ki67 LI. The patient has been in periodic follow-up and has remained in good general condition without any evidence of recurrence to date. To the best of our knowledge, the present report is the only case of systematically described pre- and post-therapy laboratory, pathology, and imaging examination results. Our report together with published studies suggest that increased awareness of synchronous PRAD risk will enable early detection and prompt therapies in patients with RCC. |
Databáze: | OpenAIRE |
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