Changes in rat lens proteins and glutathione reductase activity with advancing age
| Autor: | Kesa Kishida, Hiroko Hirano, Kumiko Katakura |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Aging
medicine.medical_specialty Endocrinology Diabetes and Metabolism Glutathione reductase Gene Expression Medicine (miscellaneous) Biology Reductase chemistry.chemical_compound Crystallin Internal medicine Lens Crystalline Gene expression medicine Animals RNA Messenger Flavin adenine dinucleotide chemistry.chemical_classification Messenger RNA Nutrition and Dietetics Body Weight Water Organ Size General Medicine Glutathione Crystallins Molecular biology Rats Glutathione Reductase Endocrinology Enzyme Solubility chemistry Flavin-Adenine Dinucleotide |
| Zdroj: | International Journal for Vitamin and Nutrition Research. 74:329-333 |
| ISSN: | 1664-2821 0300-9831 |
| DOI: | 10.1024/0300-9831.74.5.329 |
| Popis: | We examined the changes in the amounts of water-soluble and water-insoluble proteins of rat lenses, and in glutathione reductase activity and glutathione reductase gene expression, with advancing age. The lens total protein increased in 1-month-old rats, 3-month-old rats, and 6-month-old rats, but thereafter decreased in 12-month-old-rats. The water-soluble proteins decreased with advancing age, while the water-insoluble proteins increased. The glutathione reductase activity decreased with advancing age, but the decreased glutathione reductase activity almost recovered by addition of flavin adenine dinucleotide (FAD) in vitro. However, advancing age had no effect on the level of mRNA for glutathione reductase. |
| Databáze: | OpenAIRE |
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