Effects of Maternal Resveratrol on Maternal High-Fat Diet/Obesity with or without Postnatal High-Fat Diet

Autor: Hong-Ren Yu, Jiunn-Ming Sheen, Mao-Meng Tiao, Li-Tung Huang, You-Lin Tain, Mei-Hsin Hsu, I-Chun Lin
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Male
hippocampus
Placenta
Morris water navigation task
Resveratrol
Antioxidants
lcsh:Chemistry
Rats
Sprague-Dawley
chemistry.chemical_compound
Pregnancy
lcsh:QH301-705.5
Spectroscopy
biology
digestive
oral
and skin physiology
maternal high-fat diet
food and beverages
General Medicine
Computer Science Applications
maternal obesity
medicine.anatomical_structure
Prenatal Exposure Delayed Effects
Female
Adiponectin
postnatal high-fat diet
hormones
hormone substitutes
and hormone antagonists
medicine.medical_specialty
Offspring
Alpha (ethology)
Context (language use)
Weaning
Diet
High-Fat
Article
Catalysis
Inorganic Chemistry
Internal medicine
maternal resveratrol
medicine
Animals
Humans
Cognitive Dysfunction
Obesity
Physical and Theoretical Chemistry
Maze Learning
Molecular Biology
Sirtuin 1
business.industry
Brain-Derived Neurotrophic Factor
Organic Chemistry
nutritional and metabolic diseases
Maternal Nutritional Physiological Phenomena
spatial
Endocrinology
lcsh:Biology (General)
lcsh:QD1-999
chemistry
biology.protein
Insulin Resistance
business
Zdroj: International Journal of Molecular Sciences
Volume 21
Issue 10
International Journal of Molecular Sciences, Vol 21, Iss 3428, p 3428 (2020)
ISSN: 1422-0067
DOI: 10.3390/ijms21103428
Popis: To examine the effects of maternal resveratrol in rats borne to dams with gestational high-fat diet (HFD)/obesity with or without postnatal high-fat diet. We first tested the effects of maternal resveratrol intake on placenta and male fetus brain in rats borne to dams with gestational HFD/obesity. Then, we assessed the possible priming effect of a subsequent insult, male offspring were weaned onto either a rat chow or a HFD. Spatial learning and memory were assessed by Morris water maze test. Blood pressure and peripheral insulin resistance were examined. Maternal HFD/obesity decreased adiponectin, phosphorylation alpha serine/threonine-protein kinase (pAKT), sirtuin 1 (SIRT1), and brain-derived neurotrophic factor (BDNF) in rat placenta, male fetal brain, and adult male offspring dorsal hippocampus. Maternal resveratrol treatment restored adiponectin, pAKT, and BDNF in fetal brain. It also reduced body weight, peripheral insulin resistance, increased blood pressure, and alleviated cognitive impairment in adult male offspring with combined maternal HFD and postnatal HFD. Maternal resveratrol treatment restored hippocampal pAKT and BDNF in rats with combined maternal HFD and postnatal HFD in adult male offspring dorsal hippocampus. Maternal resveratrol intake protects the fetal brain in the context of maternal HFD/obesity. It effectively reduced the synergistic effects of maternal HFD/obesity and postnatal HFD on metabolic disturbances and cognitive impairment in adult male offspring. Our data suggest that maternal resveratrol intake may serve as an effective therapeutic strategy in the context of maternal HFD/obesity.
Databáze: OpenAIRE
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